Iodine quantification in dual-energy mammography: Linearity, bias and variability
Por:
Pacheco-Guevara G., Castillo-Lopez J.P., Villaseñor-Navarro Y., Brandan M-E.
Publicada:
1 ene 2022
Resumen:
Contrast-enhanced digital mammography (CEDM) is used to detect iodine uptake in breast lesions. Iodine concentrations inside or around breast lesions could be used as a biomarker, provided a properly characterized quantification method is implemented. In this work, we have evaluated a method to quantify iodine concentrations in CEDM in terms of its intrinsic linearity, bias and variability. This evaluation was performed in a virtual clinical trial (VCT) environment, simulating anthropomorphic breast phantoms containing solid and liquid lesions with different iodine concentrations. Our results showed that anatomical variables such as breast size and lesion size and composition have a considerable effect on the iodine quantification. The method was linear in the clinical iodine concentration range, and showed an approximately constant 1 mg/cm2 bias in the 0 - 2 mg/cm2 range for both solid and liquid lesions. Corrections were proposed that reduced the variability due to breast size, lesion size, and composition. © 2022 SPIE.
Filiaciones:
Pacheco-Guevara G.:
Instituto de FÃsica, Universidad Nacional Autónoma de México, Mexico City, Mexico
Castillo-Lopez J.P.:
Instituto Nacional de CancerologÃa, Mexico City, Mexico
Villaseñor-Navarro Y.:
Instituto Nacional de CancerologÃa, Mexico City, Mexico
Brandan M-E.:
Instituto de FÃsica, Universidad Nacional Autónoma de México, Mexico City, Mexico
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