Personalization of Pharmacological Treatments for ADHD: Why it is Advisable and Possible Options to Achieve it
Por:
Herrera-Morales W.V., Ramirez-Lugo, Leticia, Cauich-Kumul, Roger, Murillo-Rodriguez, Eric, Núñez-Jaramillo L.
Publicada:
1 ene 2022
Resumen:
Attention-deficit hyperactivity disorder is a neurodevelopmental
disorder diagnosed primarily in children, although it is also present in
adults. Patients present inattention, impulsivity, and hyperactivity
symptoms that create difficulties in their daily lives. Pharmacological
treatment with stimulants or non-stimulants is used most commonly to
reduce ADHD symptoms. Although generally effective and safe,
pharmacological treatments have different effects among patients,
including lack of response and adverse reactions. The reasons for these
differences are not fully understood, but they may derive from the
highly diverse etiology of ADHD. Strategies to guide optimal
pharmacological treatment selection based on individual patients'
physiological markers are being developed. In this review, we describe
the main pharmacological ADHD treatments used and their main drawbacks.
We present alternatives under study that would allow the customization
of pharmacological treatments to overcome these drawbacks and achieve
more reliable improvement of ADHD symptoms.
Filiaciones:
Herrera-Morales W.V.:
Departamento de Ciencias Médicas, División de Ciencias de la Salud, Universidad de Quintana Roo, Quintana Roo, Chetumal, Mexico
Ramirez-Lugo, Leticia:
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Cauich-Kumul, Roger:
Departamento de Ciencias Farmaceúticas, División de Ciencias de la Salud, Universidad de Quintana Roo, Quintana Roo, Chetumal, Mexico
Murillo-Rodriguez, Eric:
Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medi-cina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Mexico
Intercontinental Neuroscience Research Group, Yucatán, Mérida, Mexico
Núñez-Jaramillo L.:
Departamento de Ciencias Médicas, División de Ciencias de la Salud, Universidad de Quintana Roo, Quintana Roo, Chetumal, Mexico
|