Probiotic Monotherapy with Lactobacillus reuteri (Prodentis) as a Coadjutant to Reduce Subgingival Dysbiosis in a Patient with Periodontitis
Por:
Salinas-Azuceno C., Martínez-Hernández M., Maldonado-Noriega J.-I., Rodríguez-Hernández A.-P., Ximenez-Fyvie L.-A.
Publicada:
1 ene 2022
Resumen:
(1) Background: Probiotics can be considered a non-invasive periodontal monotherapy for the modulation of microbiota when periodontal treatment is not accessible. The aim was to evaluate the ability of Lactobacillus reuteri Prodentis as monotherapy to modulate periodontal parameters and subgingival biofilm dysbiosis. (2) Methods: A 30-year-old patient with periodontitis was followed longitudinally after one month of daily consumption of L. reuteri Prodentis (T0). Periodontal measurements and microbial identification by Checkerboard DNA–DNA hybridization of 40 bacteria were compared between baseline (T0) and 30 days (T1) or 90 days (T2), using the Kruskal–Wallis (KW) and Mann–Whitney U (MW) tests. (3) Results: Low values of pocket depth, attachment level, dental plaque, gingival erythema (GE), and suppuration were observed at T0 vs. T1, with the clinical improvement of GE (p < 0.05, MW) and the recovery of tooth 46 fistulation. T1 vs. T0 comparisons showed lower levels (Lev) or proportions (Prop) of Parvimonas micra (Lev: p < 0.05, MW; Prop: p < 0.01, MW) and Streptococcus gordonii (Prop: p < 0.05, MW), and a predominance (Lev/Prop) of Actinomyces odontolyticus and Streptococcus mitis; lower levels and proportions of P. micra, Eubacterium saburreum, Porphyromonas gingivalis, and Tannerella forsythia were observed in tooth 46 (T1/T2 vs. T0). (4) Conclusions: Under monotherapy with L. reuteri Prodentis, periodontal measurements of the patient were maintained, with selective changes in the subgingival microbiota that were proportional to the time of probiotic administration, with any additional periodontal treatment. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Salinas-Azuceno C.:
Laboratorio de Genética Molecular, Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04360, Mexico
Martínez-Hernández M.:
Laboratorio de Genética Molecular, Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04360, Mexico
Maldonado-Noriega J.-I.:
Centro de Estudios Superiores de Ortodoncia (CESO), Nicolás San Juan 1628, Ciudad de México, 03100, Mexico
Rodríguez-Hernández A.-P.:
Laboratorio de Genética Molecular, Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04360, Mexico
Ximenez-Fyvie L.-A.:
Laboratorio de Genética Molecular, Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04360, Mexico
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