Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation
Por:
Nava-Gomez, L., Calero-Vargas, I, Higinio-Rodriguez, F., Vazquez-Prieto, B., Olivares-Moreno, R., Ortiz-Retana, J., Aranda, P., Hernandez-Chan, N., Rojas-Piloni, G., Alcauter, S., Lopez-Hidalgo, M.
Publicada:
1 may 2022
Resumen:
Brain aging is a natural process that involves structural and functional
changes that lead to cognitive decline, even in healthy subjects. This
detriment has been associated with NMDA receptor (NMDAR) hypofunction
because of a reduction in the brain levels of D-serine, the endogenous
NMDAR co-agonist. However, it is not clear whether D-serine
supplementation could be used as an intervention to reduce or reverse
age-related brain alterations. In the present work, we aimed to analyze
the D-serine effect on aging-associated alterations in cellular and
large-scale brain systems that could support cognitive flexibility in
rats. We found that D-serine supplementation reverts the age-related
decline in cognitive flexibility, frontal dendritic spine density, and
partially restored large-scale functional connectivity without inducing
nephrotoxicity; instead, D-serine restored the thickness of the renal
epithelial cells that were affected by age. Our results suggest that
D-serine could be used as a therapeutic target to reverse age-related
brain alterations.
Filiaciones:
Nava-Gomez, L.:
Univ Nacl Autonoma Mexico, Escuela Nacl Estudios Super, Queretaro 76230, Mexico
Univ Autonoma Queretaro, Fac Med, Queretaro 76126, Mexico
Calero-Vargas, I:
Univ Nacl Autonoma Mexico, Escuela Nacl Estudios Super, Queretaro 76230, Mexico
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro 76230, Mexico
Higinio-Rodriguez, F.:
Univ Nacl Autonoma Mexico, Escuela Nacl Estudios Super, Queretaro 76230, Mexico
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro 76230, Mexico
Vazquez-Prieto, B.:
Univ Nacl Autonoma Mexico, Escuela Nacl Estudios Super, Queretaro 76230, Mexico
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro 76230, Mexico
Olivares-Moreno, R.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro 76230, Mexico
Ortiz-Retana, J.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro 76230, Mexico
Aranda, P.:
Univ Autonoma Queretaro, Fac Ciencias Nat, Queretaro 76230, Mexico
Hernandez-Chan, N.:
Univ Autonoma Queretaro, Fac Ingn, Queretaro 76010, Mexico
Rojas-Piloni, G.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro 76230, Mexico
Alcauter, S.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro 76230, Mexico
Lopez-Hidalgo, M.:
(Corresponding Author), Univ Nacl Autonoma Mexico, Escuela Nacl Estudios Super, Queretaro 76230, Mexico
Univ Nacl Autonoma Mexico, Escuela Nacl Estudios Super, Queretaro 76230, Mexico
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