Omega-6 Polyunsaturated Fatty Acids Enhance Tumor Aggressiveness in Experimental Lung Cancer Model: Important Role of Oxylipins
Por:
Montecillo-Aguado, Mayra, Tirado-Rodriguez, Belen, Antonio-Andres, Gabriela, Morales-Martinez, Mario, Tong, Zhen, Yang, Jun, Hammock, Bruce D., Hernandez-Pando, Rogelio, Huerta-Yepez, Sara
Publicada:
1 jun 2022
Resumen:
Lung cancer is currently the leading cause of cancer death worldwide; it
is often diagnosed at an advanced stage and bears poor prognosis. It has
been shown that diet is an important environmental factor that
contributes to the risk and mortality of several types of cancers.
Intake of omega-3 and omega-6 PUFAs plays an important role in cancer
risk and progression. Current Western populations have high consumption
of omega-6 PUFAs with a ratio of omega-6/omega-3 PUFAs at 15:1 to 16.7:1
This high consumption of omega-6 PUFAs is related to increased cancer
risk and progression. However, whether a diet rich in omega-6 PUFAs can
contribute to tumor aggressiveness has not been well investigated. We
used a murine model of pulmonary squamous cell carcinoma to study the
aggressiveness of tumors in mice fed with a diet rich in omega-6 PUFAs
and its relationship with oxylipins. Our results shown that the mice fed
a diet rich in omega-6 showed a marked increase in proliferation,
angiogenesis and proinflammatory markers and decreased expression of
pro-apoptotic proteins in their tumors. Oxylipin profiling revealed an
upregulation of various pro-tumoral oxylipins including PGs, HETEs,
DiHETrEs and HODEs. These results demonstrate for the first time that
high intake of omega-6 PUFAs in the diet enhances the malignancy of
tumor cells by histological changes on tumor dedifferentiation and
increases cell proliferation, angiogenesis, pro-inflammatory oxylipins
and molecular aggressiveness targets such as NF-kappa B p65, YY1, COX-2
and TGF-beta.
Filiaciones:
Montecillo-Aguado, Mayra:
Univ Nacl Autonoma Mexico, Fac Med, Programa Doctorado Ciencias Biomed, Mexico City 04510, DF, Mexico
Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Enfermedades Oncol, Mexico City 06720, DF, Mexico
Tirado-Rodriguez, Belen:
Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Enfermedades Oncol, Mexico City 06720, DF, Mexico
Antonio-Andres, Gabriela:
Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Enfermedades Oncol, Mexico City 06720, DF, Mexico
Morales-Martinez, Mario:
Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Enfermedades Oncol, Mexico City 06720, DF, Mexico
Tong, Zhen:
Univ Calif Los Angeles, Mol Toxicol Interdept Program & Environm Hlth Sci, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Yang, Jun:
Univ Calif Davis, Comprehens Canc Ctr, Dept Entomol & Nematol, Davis, CA 95616 USA
Hammock, Bruce D.:
Univ Calif Davis, Comprehens Canc Ctr, Dept Entomol & Nematol, Davis, CA 95616 USA
Hernandez-Pando, Rogelio:
Natl Inst Med Sci & Nutr, Dept Pathol, Expt Pathol Sect, Salvador Zubiran INCNSZ, Mexico City 14080, DF, Mexico
Huerta-Yepez, Sara:
Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Enfermedades Oncol, Mexico City 06720, DF, Mexico
Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
gold, Green Published, Gold, Green
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