Rheumatoid arthritis-related interstitial lung disease (RA-ILD): a possible association between disease activity and prognosis
Por:
Rojas-Serrano, Jorge, Mejia, Mayra, Rivera-Matias, Pedro A., Herrera-Bringas, Denisse, Perez-Roman, I, Diana, Perez-Dorame, Renzo, Mateos-Toledo, Heidegger
Publicada:
1 jun 2022
Resumen:
Objectives We hypothesized that RA disease activity might be associated
with the survival of RA-ILD patients. To evaluate this possibility, we
analyzed data on disease activity during follow-up in an RA-ILD cohort
and compared disease activity between surviving patients and those who
died during follow-up.
Methods RA-ILD patients referred for medical evaluation and treatment at
a single center, with CDAI scores during all follow up were included. We
estimated the HR of the mean of the CDAI score during follow-up with
survival. Also, we compared the survival function of patients with high
disease activity (CDAI scores >= 22) during all follow-up with those
with moderate and low disease activity.
Results Thirty-seven patients were included. The mean of the CDAI score
during follow-up was higher in death patients (median 30.8 +/- 18.5 Vs.
16.8 +/- 11.3), and a single unit increase in the mean of the CDAI score
was associated with non-survival, HR:1.07 (95% CI: 1.02 -1.12).
Patients with high disease activity during all follow-up (CDAI scores >
22) had lower survival function in comparison with moderate and low
disease activity (P = 0.042).
Conclusion The results of the study suggest that higher RA disease
activity is associated with a worse prognosis of RA-ILD patients. The
hypothesis that high disease activity is associated with worse survival
in RA-ILD patients must be evaluated in more extensive cohort studies
and clinical trials.
Filiaciones:
Rojas-Serrano, Jorge:
Perez-Roman, Diana, I , Inst Nacl Enfermedades Resp, Interstitial Lung Dis & Rheumatol Unit, Calzada Tlalpan 4502,Secc 16, Mexico City 14080, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Programa Maestria & Doctorado Ciencias Med, Coyoacan, Mexico
Mejia, Mayra:
Perez-Roman, Diana, I , Inst Nacl Enfermedades Resp, Interstitial Lung Dis & Rheumatol Unit, Calzada Tlalpan 4502,Secc 16, Mexico City 14080, DF, Mexico
Rivera-Matias, Pedro A.:
Perez-Roman, Diana, I , Inst Nacl Enfermedades Resp, Interstitial Lung Dis & Rheumatol Unit, Calzada Tlalpan 4502,Secc 16, Mexico City 14080, DF, Mexico
Herrera-Bringas, Denisse:
Perez-Roman, Diana, I , Inst Nacl Enfermedades Resp, Interstitial Lung Dis & Rheumatol Unit, Calzada Tlalpan 4502,Secc 16, Mexico City 14080, DF, Mexico
Perez-Dorame, Renzo:
Perez-Roman, Diana, I , Inst Nacl Enfermedades Resp, Interstitial Lung Dis & Rheumatol Unit, Calzada Tlalpan 4502,Secc 16, Mexico City 14080, DF, Mexico
Mateos-Toledo, Heidegger:
Perez-Roman, Diana, I , Inst Nacl Enfermedades Resp, Interstitial Lung Dis & Rheumatol Unit, Calzada Tlalpan 4502,Secc 16, Mexico City 14080, DF, Mexico
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