Extracellular vesicles from blood of breast cancer women induce angiogenic processes in HUVECs
Por:
Garcia-Hernandez, Alejandra, Reyes-Uribe, Emmanuel, Arce-Salinas, Claudia, de la Cruz-Lopez K.-G., Manzo-Merino, Joaquin, Guzman-Ortiz A.-L., Quezada, Hector, Cortes-Reynosa, Pedro, Breton-Mora, Fernando, Elizalde-Acosta, Irma, Thompson-Bonilla, Rocio, Salazar E.P.
Publicada:
1 jun 2022
Resumen:
Breast cancer is the most frequent malignancy among women in developed
countries and the main cause of death related to cancer in women
worldwide. Extracellular vesicles (EVs) are vesicles with a variable
size enclosed within a phospholipid bilayer that contain a variety of
molecules with biological activity. Cancer cells release EVs that induce
proliferation, escape from apoptosis, reprogramming energy metabolism,
invasion and metastasis. In this study we studied whether EV fractions
deprived of platelet EVs from breast cancer women (BC EVs) can mediate
cell processes related with angiogenesis in human umbilical vein
endothelial cells (HUVECs). Our findings demonstrate that BC EVs enhance
migration, invasion and formation of new tubules in HUVECs, compared
with EV fractions deprived of platelet EVs from healthy women (Ctrl
EVs). In summary, we demonstrate, for the first time, that BC EVs induce
cellular processes in HUVECs that participate in angiogenesis.
Filiaciones:
Garcia-Hernandez, Alejandra:
Departamento de Biologia Celular, CINVESTAV-IPN, Ciudad de Mexico, 07360, Mexico
CINVESTAV IPN, Dept Biol Celular, Ciudad De Mexico 07360, Mexico
Reyes-Uribe, Emmanuel:
Departamento de Ciencias Medicas y de la Vida, Centro Universitario la Cienaga, Universidad de Guadalajara, Jalisco47810, Mexico
Univ Guadalajara, Ctr Univ Cienaga, Dept Ciencias Med & Vida, Guadalajara 47810, Jalisco, Mexico
Arce-Salinas, Claudia:
Departamento de Oncologia Medica, Instituto Nacional de Cancerologia, Ciudad de Mexico, 14080, Mexico
Inst Nacl Cancerol, Dept Oncol Med, Ciudad De Mexico 14080, Mexico
de la Cruz-Lopez K.-G.:
Instituto de Investigaciones Biomedicas, UNAM, Ciudad de Mexico, 04510, Mexico
Manzo-Merino, Joaquin:
Catedras CONACYT, Instituto Nacional de Cancerologia, Ciudad de Mexico, 07360, Mexico
Inst Nacl Cancerol, Catedras CONACYT, Ciudad De Mexico 07360, Mexico
Guzman-Ortiz A.-L.:
Laboratorio de Investigacion en Inmunologia y Proteomica. Hospital Infantil de Mexico, Federico Gomez, Ciudad de Mexico, 06720, Mexico
Quezada, Hector:
Laboratorio de Investigacion en Inmunologia y Proteomica. Hospital Infantil de Mexico, Federico Gomez, Ciudad de Mexico, 06720, Mexico
Hosp Infantil Mexico Dr Federico Gomez, Lab Invest Inmunol & Proteom, Ciudad De Mexico 06720, Mexico
Cortes-Reynosa, Pedro:
Departamento de Biologia Celular, CINVESTAV-IPN, Ciudad de Mexico, 07360, Mexico
CINVESTAV IPN, Dept Biol Celular, Ciudad De Mexico 07360, Mexico
Breton-Mora, Fernando:
Hospital General Dr. Fernando Quiroz-ISSSTE, Ciudad de Mexico, 01140, Mexico
Hosp Gen Dr Fernando Quiroz ISSSTE, Ciudad De Mexico 01140, Mexico
Elizalde-Acosta, Irma:
Hospital Regional 1º de Octubre-ISSSTE, Ciudad de Mexico, 07760, Mexico
Hosp Reg 1 Octubre ISSSTE, Ciudad De Mexico 07760, Mexico
Thompson-Bonilla, Rocio:
Hospital Regional 1º de Octubre-ISSSTE, Ciudad de Mexico, 07760, Mexico
Hosp Reg 1 Octubre ISSSTE, Ciudad De Mexico 07760, Mexico
Salazar E.P.:
Departamento de Biologia Celular, CINVESTAV-IPN, Ciudad de Mexico, 07360, Mexico
UNAM, Inst Invest Biomed, Ciudad De Mexico 04510, Mexico
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