Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium
Por:
Fernandez-Rhodes, Lindsay, Graff, Mariaelisa, Buchanan, Victoria L., Justice, Anne E., Highland, Heather M., Guo, Xiuqing, Zhu, Wanying, Chen H.-H., Young, Kristin L., Adhikari, Kaustubh, Palmer, Nicholette D., Below, Jennifer E., Bradfield, Jonathan, Pereira, Alexandre C., Glover, LaShaunta, Kim, Daeeun, Lilly, Adam G., Shrestha, Poojan, Thomas, Alvin G., Zhang, Xinruo, Chen, Minhui, Chiang C.W.K., Pulit, Sara, Horimoto, Andrea, Krieger, Jose E., Guindo-Martinez, Marta, Preuss, Michael, Schumann, Claudia, Smit R.A.J., Torres-Mejia, Gabriela, Acuña-Alonzo V., Bedoya, Gabriel, Bortolini M.-C., Canizales-Quinteros, Samuel, Gallo, Carla, Gonzalez-Jose, Rolando, Poletti, Giovanni, Rothhammer, Francisco, Hakonarson, Hakon, Igo, Robert, Adler, Sharon G., Iyengar, Sudha K., Nicholas, Susanne B., Gogarten, Stephanie M., Isasi, Carmen R., Papnicolaou, George, Stilp, Adrienne M., Qi, Qibin, Kho, Minjung, Smith, Jennifer A., Langefeld, Carl D., Wagenknecht, Lynne, Mckean-Cowdin, Roberta, Gao, Xiaoyi Raymond, Nousome, Darryl, Conti, V, David, Feng, Ye, Allison, Matthew A., Arzumanyan, Zorayr, Buchanan, Thomas A., Ida Chen Y.-D., Genter, Pauline M., Goodarzi, Mark O., Hai, Yang, Hsueh, Willa, Ipp, Eli, Kandeel, Fouad R., Lam, Kelvin, Li, Xiaohui, Nadler, Jerry L., Raffel, Leslie J., Roll, Kathryn, Sandow, Kevin, Tan, Jingyi, Taylor, Kent D., Xiang, Anny H., Yao, Jie, Audirac-Chalifour, Astride, de Jesus Peralta Romero J., Hartwig, Fernando, Horta, Bernando, Blangero, John, Curran, Joanne E., Duggirala, Ravindranath, Lehman, Donna E., Puppala, Sobha, Fejerman, Laura, John, Esther M., Aguilar-Salinas, Carlos, Burtt, Noel P., Florez, Jose C., Garcia-Ortiz, Humberto, Gonzalez-Villalpando, Clicerio, Mercader, Josep, Orozco, Lorena, Tusie-Luna, Teresa, Blanco, Estela, Gahagan, Sheila, Cox, Nancy J., Hanis, Craig, Butte, Nancy F., Cole, Shelley A., Comuzzie, Anthony G., Voruganti, V. Saroja, Rohde, Rebecca, Wang, Yujie, Sofer, Tamar, Ziv, Elad, Grant S.F.A., Ruiz-Linares, Andres, Rotter, I, Jerome, Haiman, Christopher A., Parra, Esteban J., Cruz, Miguel, Loos R.J.F., North, Kari E.
Publicada:
14 abr 2022
Resumen:
Hispanic/Latinos have been underrepresented in genome-wide association
studies (GWAS) for anthropometric traits despite their notable
anthropometric variability, ancestry proportions, and high burden of
growth stunting and overweight/obesity. To address this knowledge gap,
we analyzed densely imputed genetic data in a sample of Hispanic/Latino
adults to identify and fine-map genetic variants associated with body
mass index (BMI), height, and BMI-adjusted waist-to-hip ratio
(WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the
Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771)
and generalized our findings in 9 additional studies (stage 2, n =
10,538). We conducted a trans-ancestral GWAS with summary statistics
from HISLA stage 1 and existing consortia of European and African
ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI
locus, as well as two BMI signals and another height signal each within
established anthropometric loci. In our trans-ancestral meta-analysis,
we discovered three BMI loci, one height locus, and one WHRadjBMI locus.
We also identified 3 secondary signals for BMI, 28 for height, and 2 for
WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known
height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive
transferability (nominal significance and effect estimate directional
consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height,
and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni
correction. Trans-ancestral meta-analysis of the three ancestries showed
a small-to-moderate impact of uncorrected population stratification on
the resulting effect size estimates. Our findings demonstrate that
future studies may also benefit from leveraging diverse ancestries and
differences in linkage disequilibrium patterns to discover novel loci
and additional signals with less residual population stratification.
Filiaciones:
Fernandez-Rhodes, Lindsay:
Department of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, United States
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Penn State Univ, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
219 Biobehav Hlth Bldg, University Pk, PA 16802 USA
Graff, Mariaelisa:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
123 West Franklin St,Bldg C,Campus Box 8050, Chapel Hill, NC 27599 USA
Buchanan, Victoria L.:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Justice, Anne E.:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA 17822, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Geisinger Hlth Syst, Dept Biomed & Translat Informat, Danville, PA 17822 USA
Highland, Heather M.:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Guo, Xiuqing:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Zhu, Wanying:
Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, United States
Vanderbilt Univ Sch Med, Vanderbilt Genet Inst, Dept Med, Div Genet Med, Nashville, TN 37232 USA
Chen H.-H.:
Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, United States
Young, Kristin L.:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Adhikari, Kaustubh:
School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, MK7 6AA, United Kingdom
Open Univ, Fac Sci Technol Engn & Math, Sch Math & Stat, Milton Keynes MK7 6AA, Bucks, England
Palmer, Nicholette D.:
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27101, United States
Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27101 USA
Below, Jennifer E.:
Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, United States
Vanderbilt Univ Sch Med, Vanderbilt Genet Inst, Dept Med, Div Genet Med, Nashville, TN 37232 USA
Bradfield, Jonathan:
Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States
Childrens Hosp Philadelphia, Ctr Appl Genom, Dept Pediat, Div Human Genet, Philadelphia, PA 19104 USA
Pereira, Alexandre C.:
Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, 05508-220, Brazil
Univ Sao Paulo, Heart Inst, Lab Genet & Mol Cardiol, BR-05508220 Sao Paulo, Brazil
Glover, LaShaunta:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Kim, Daeeun:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Lilly, Adam G.:
Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Sociol, Chapel Hill, NC 27599 USA
Univ North Carolina Chapel Hill, Carolina Populat Ctr, Chapel Hill, NC 27599 USA
Shrestha, Poojan:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Univ North Carolina Chapel Hill, Div Pediat & Publ Hlth, Adams Sch Dent, Chapel Hill, NC 27599 USA
Thomas, Alvin G.:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Zhang, Xinruo:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Chen, Minhui:
Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
Conti, David, V , Univ Southern Calif, Ctr Genet Epidemiol, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
Chiang C.W.K.:
Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90007, United States
Pulit, Sara:
Vertex Pharmaceuticals, Oxford, W2 6BD, United Kingdom
Vertex Pharmaceut, Oxford W2 6BD, England
Horimoto, Andrea:
Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, 05508-220, Brazil
Univ Sao Paulo, Heart Inst, Lab Genet & Mol Cardiol, BR-05508220 Sao Paulo, Brazil
Krieger, Jose E.:
Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, 05508-220, Brazil
Univ Sao Paulo, Heart Inst, Lab Genet & Mol Cardiol, BR-05508220 Sao Paulo, Brazil
Guindo-Martinez, Marta:
The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
The Novo Nordisk Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, 2200, Denmark
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
Univ Copenhagen, Novo Nordisk Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark
Preuss, Michael:
The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
Schumann, Claudia:
Hasso Plattner Institute, University of Potsdam, Digital Health Center, Potsdam, 14482, Germany
Univ Potsdam, Digital Hlth Ctr, Hasso Plattner Inst, D-14482 Potsdam, Germany
Smit R.A.J.:
The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Torres-Mejia, Gabriela:
Department of Research in Cardiovascular Diseases, Diabetes Mellitus, and Cancer, Population Health Research Center, National Institute of Public Health, Morelos, Cuernavaca, 62100, Mexico
Natl Inst Publ Hlth, Populat Hlth Res Ctr, Dept Res Cardiovasc Dis Diabet Mellitus & Canc, Cuernavaca 62100, Morelos, Mexico
Acuña-Alonzo V.:
National Institute of Anthropology and History, Mexico City, 06600, Mexico
Bedoya, Gabriel:
Molecular Genetics Investigation Group, University of Antioquia, Medellín, 1226, Colombia
Univ Antioquia, Mol Genet Invest Grp, Medellin 1226, Colombia
Bortolini M.-C.:
Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, 90040-060, Brazil
Canizales-Quinteros, Samuel:
Population Genomics Applied to Health Unit, The National Institute of Genomic Medicine and the Faculty of Chemistry at the National Autonomous University of Mexico, Mexico City, 04510, Mexico
Univ Nacl Autonoma Mexico, Populat Genom Appl Hlth Unit, Natl Inst Genom Med, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Chem, Mexico City 04510, DF, Mexico
Gallo, Carla:
Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 15102, Peru
Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Labs Invest & Desarrollo, Lima 15102, Peru
Gonzalez-Jose, Rolando:
Patagonian Institute of the Social and Human Sciences, Patagonian National Center, Puerto Madryn, U9120, Argentina
Patagonian Natl Ctr, Patagonian Inst Social & Human Sci, Puerto Madryn U9120, Puerto Madryn, Argentina
Poletti, Giovanni:
Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 15102, Peru
Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Labs Invest & Desarrollo, Lima 15102, Peru
Rothhammer, Francisco:
Institute of High Studies, University of Tarapacá, Arica, 1000000, Chile
Univ Tarapaca, Inst High Studies, Arica 1000000, Chile
Hakonarson, Hakon:
Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States
Childrens Hosp Philadelphia, Ctr Appl Genom, Dept Pediat, Div Human Genet, Philadelphia, PA 19104 USA
Igo, Robert:
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, United States
Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA
Adler, Sharon G.:
Division of Nephrology and Hypertension, Harbor-University of California Los Angeles Medical Center, Torrance, CA 90502, United States
Harbor Univ Calif Los Angeles Med Ctr, Div Nephrol & Hypertens, Torrance, CA 90502 USA
Iyengar, Sudha K.:
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, United States
Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA
Nicholas, Susanne B.:
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, United States
Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Los Angeles, CA 90095 USA
Gogarten, Stephanie M.:
Department of Biostatistics, University of Washington, Seattle, WA 98195, United States
Univ Washington, Dept Biostat, Seattle, WA 98195 USA
Isasi, Carmen R.:
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, United States
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
Papnicolaou, George:
National Heart, Lung and Blood Institute, Bethesda, MD 20892, United States
NHLBI, Bethesda, MD 20892 USA
Stilp, Adrienne M.:
Department of Biostatistics, University of Washington, Seattle, WA 98195, United States
Univ Washington, Dept Biostat, Seattle, WA 98195 USA
Qi, Qibin:
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, United States
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
Kho, Minjung:
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, United States
Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
Smith, Jennifer A.:
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, United States
Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
Langefeld, Carl D.:
Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC 27101, United States
Wake Forest Sch Med, Dept Biostat & Data Sci, Winston Salem, NC 27101 USA
Wagenknecht, Lynne:
Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101, United States
Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27101 USA
Mckean-Cowdin, Roberta:
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, United States
Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90032 USA
Gao, Xiaoyi Raymond:
Department of Ophthalmology and Visual Sciences, Department of Biomedical Informatics, Division of Human Genetics, The Ohio State University, Columbus, OH 43210, United States
Ohio State Univ, Dept Ophthalmol & Visual Sci, Dept Biomed Informat, Div Human Genet, Columbus, OH 43210 USA
Nousome, Darryl:
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, United States
Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90032 USA
Conti, V, David:
Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
Feng, Ye:
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, United States
Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90032 USA
Allison, Matthew A.:
Department of Family Medicine, University of California, San Diego, CA 92161, United States
Univ Calif San Diego, Dept Family Med, San Diego, CA 92161 USA
Arzumanyan, Zorayr:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Buchanan, Thomas A.:
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA
Ida Chen Y.-D.:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Genter, Pauline M.:
Department of Medicine, Division of Endocrinology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Harbor UCLA Med Ctr, Dept Med, Div Endocrinol, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Goodarzi, Mark O.:
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States
Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA
Hai, Yang:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Hsueh, Willa:
Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Ohio State Univ, Dept Internal Med, Wexner Med Ctr, Columbus, OH 43210 USA
Ipp, Eli:
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, United States
Department of Medicine, Division of Endocrinology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Los Angeles, CA 90095 USA
Harbor UCLA Med Ctr, Dept Med, Div Endocrinol, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Kandeel, Fouad R.:
Department of Translational Research & Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, United States
City Hope Natl Med Ctr, Dept Translat Res & Cellular Therapeut, Beckman Res Inst, Duarte, CA 91010 USA
Lam, Kelvin:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Li, Xiaohui:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Nadler, Jerry L.:
Department of Pharmacology at New York Medical College School of Medicine, Valhalla, NY 10595, United States
New York Med Coll, Dept Pharmacol, Sch Med, Valhalla, NY 10595 USA
Raffel, Leslie J.:
Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA 92697, United States
Univ Calif Irvine, Dept Pediat, Div Genet & Genom Med, Irvine, CA 92697 USA
Roll, Kathryn:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Sandow, Kevin:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Tan, Jingyi:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Taylor, Kent D.:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Xiang, Anny H.:
Research and Evaluation Branch, Kaiser Permanente of Southern California, Pasadena, CA 91101, United States
Kaiser Permanente Southern Calif, Res & Evaluat Branch, Pasadena, CA 91101 USA
Yao, Jie:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Rotter, Jerome, I, Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90502 USA
Audirac-Chalifour, Astride:
Medical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City, 06725, Mexico
Mexican Inst Social Secur, Natl Med Ctr Twenty First Century, Specialty Hosp, Med Res Unit Biochem, Mexico City 06725, DF, Mexico
de Jesus Peralta Romero J.:
Medical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City, 06725, Mexico
Hartwig, Fernando:
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, 96010-610, Brazil
Univ Fed Pelotas, Postgrad Program Epidemiol, BR-96010610 Pelotas, RS, Brazil
Horta, Bernando:
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, 96010-610, Brazil
Univ Fed Pelotas, Postgrad Program Epidemiol, BR-96010610 Pelotas, RS, Brazil
Blangero, John:
Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, United States
Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX 78520 USA
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX 78539 USA
Curran, Joanne E.:
Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, United States
Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX 78520 USA
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX 78539 USA
Duggirala, Ravindranath:
Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, United States
Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX 78520 USA
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX 78539 USA
Lehman, Donna E.:
Department of Medicine, School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, United States
Univ Texas Hlth San Antonio, Sch Med, Dept Med, San Antonio, TX 78229 USA
Puppala, Sobha:
Department of Internal Medicine, Section of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, United States
Wake Forest Sch Med, Dept Internal Med, Sect Mol Med, Winston Salem, NC 27109 USA
Fejerman, Laura:
Department of Public Health Sciences, School of Medicine, and the Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, United States
Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA 95616 USA
Univ Calif Davis, Comprehens Canc Ctr, Davis, CA 95616 USA
John, Esther M.:
Departments of Epidemiology & Population Health and Medicine-Oncology, Stanford University School of Medicine, Stanford, CA 94305, United States
Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Dept Med Oncol, Stanford, CA 94305 USA
Aguilar-Salinas, Carlos:
Division of Nutrition, Salvador Zubirán National Institute of Health Sciences and Nutrition, Mexico City, 14080, Mexico
Salvador Zubiran Natl Inst Hlth Sci & Nutr, Div Nutr, Mexico City 14080, DF, Mexico
Burtt, Noel P.:
Programs in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, United States
Broad Inst MIT & Harvard, Program Metab & Med, Cambridge, MA 02142 USA
Broad Inst MIT & Harvard, Program Populat Genet, Cambridge, MA 02142 USA
Florez, Jose C.:
Programs in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, United States
Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, United States
Broad Inst MIT & Harvard, Program Metab & Med, Cambridge, MA 02142 USA
Broad Inst MIT & Harvard, Program Populat Genet, Cambridge, MA 02142 USA
Harvard Med Sch, Dept Med, Boston, MA 02115 USA
Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA
Garcia-Ortiz, Humberto:
Laboratory of Immunogenomics and Metabolic Diseases, National Institute of Genomic Medicine, Mexico City, 14610, Mexico
Natl Inst Genom Med, Lab Immunogen & Metab Dis, Mexico City 14610, DF, Mexico
Gonzalez-Villalpando, Clicerio:
Center for Diabetes Studies, Research Unit for Diabetes and Cardiovascular Risk, Center for Population Health Studies, National Institute of Public Health, Mexico City, 14080, Mexico
Natl Inst Publ Hlth, Ctr Populat Hlth Studies, Ctr Diabet Studies, Res Unit Diabet & Cardiovasc Risk, Mexico City 14080, DF, Mexico
Mercader, Josep:
Programs in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, United States
Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, United States
Broad Inst MIT & Harvard, Program Metab & Med, Cambridge, MA 02142 USA
Broad Inst MIT & Harvard, Program Populat Genet, Cambridge, MA 02142 USA
Harvard Med Sch, Dept Med, Boston, MA 02115 USA
Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA
Orozco, Lorena:
Laboratory of Immunogenomics and Metabolic Diseases, National Institute of Genomic Medicine, Mexico City, 14610, Mexico
Natl Inst Genom Med, Lab Immunogen & Metab Dis, Mexico City 14610, DF, Mexico
Tusie-Luna, Teresa:
Molecular Biology and Medical Genomics Unity, Institute of Biomedical Research, The National Autonomous University of Mexico and the Salvador Zubirán National Institute of Health Sciences and Nutrition, Mexico City, 14080, Mexico
Univ Nacl Autonoma Mexico, Inst Biomed Res, Mol Biol & Med Genom Unity, Mexico City 14080, DF, Mexico
Salvador Zubiran Natl Inst Hlth Sci & Nutr, Mexico City 14080, DF, Mexico
Blanco, Estela:
Center for Community Health, Division of Academic General Pediatrics, University of California at San Diego, San Diego, CA 92093, United States
Univ Calif San Diego, Div Acad Gen Pediat, Ctr Community Hlth, San Diego, CA 92093 USA
Gahagan, Sheila:
Center for Community Health, Division of Academic General Pediatrics, University of California at San Diego, San Diego, CA 92093, United States
Univ Calif San Diego, Div Acad Gen Pediat, Ctr Community Hlth, San Diego, CA 92093 USA
Cox, Nancy J.:
Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, United States
Vanderbilt Univ Sch Med, Vanderbilt Genet Inst, Dept Med, Div Genet Med, Nashville, TN 37232 USA
Hanis, Craig:
University of Texas Health Science Center at Houston, Houston, TX 77030, United States
Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA
Butte, Nancy F.:
United States Department of Agriculture, Agricultural Research Service, The Children's Nutrition Research Center, and the Department Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States
Baylor Coll Med, USDA, ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
Cole, Shelley A.:
Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227, United States
Texas Biomed Res Inst, Populat Hlth Program, San Antonio, TX 78227 USA
Comuzzie, Anthony G.:
The Obesity Society, Silver Spring, MD 20910, United States
Obes Soc, Silver Spring, MD 20910 USA
Voruganti, V. Saroja:
Department of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, United States
Univ North Carolina Chapel Hill, Dept Nutr, Kannapolis, NC 28081 USA
Univ North Carolina Chapel Hill, Nutr Res Inst, Kannapolis, NC 28081 USA
Rohde, Rebecca:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Wang, Yujie:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Sofer, Tamar:
Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, United States
Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, United States
Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA
Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Ziv, Elad:
Division of General Internal Medicine, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94115, United States
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Inst Human Genet, Dept Med,Div Gen Internal Med, San Francisco, CA 94115 USA
Grant S.F.A.:
Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States
Ruiz-Linares, Andres:
Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200438, China
Department of Genetics, Evolution and Environment, and Genetics Institute of the University College London, London, WC1E 6BT, United Kingdom
Laboratory of Biocultural Anthropology, Law, Ethics, and Health, Aix-Marseille University, Marseille, 13385, France
Fudan Univ, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200438, Peoples R China
Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
Fudan Univ, Human Phenome Inst, Shanghai 200438, Peoples R China
UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England
UCL, Genet Inst, London WC1E 6BT, England
Aix Marseille Univ, Lab Biocultural Anthropol Law Eth & Hlth, F-13385 Marseille, France
Rotter, I, Jerome:
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, United States
Haiman, Christopher A.:
Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
Conti, David, V , Univ Southern Calif, Ctr Genet Epidemiol, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
Parra, Esteban J.:
Department of Anthropology, University of Toronto- Mississauga, Mississauga, ON L5L 1C6, Canada
Univ Toronto Mississauga, Dept Anthropol, Mississauga, ON L5L 1C6, Canada
Cruz, Miguel:
Medical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City, 06725, Mexico
Mexican Inst Social Secur, Natl Med Ctr Twenty First Century, Specialty Hosp, Med Res Unit Biochem, Mexico City 06725, DF, Mexico
Loos R.J.F.:
The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
North, Kari E.:
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, United States
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
Univ North Carolina Chapel Hill, Carolina Ctr Genome Sci, Chapel Hill, NC 27514 USA
Univ Southern Calif, Dept Quantitat & Computat Biol, Los Angeles, CA 90007 USA
Natl Inst Anthropol & Hist, Mexico City 06600, DF, Mexico
Univ Fed Rio Grande do Sul, Dept Genet, BR-90040060 Porto Alegre, RS, Brazil
Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
Green Accepted, Green Submitted, Green Published, gold, Gold, Green
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