Redox-sensitive signaling pathways in renal cell carcinoma
Por:
Cruz-Gregorio, Alfredo, Karina Aranda-Rivera, Ana, Pedraza-Chaverri, Jose, Solano, Jose D., Elena Ibarra-Rubio, Maria
Publicada:
1 mar 2022
Ahead of Print:
1 sep 2021
Resumen:
Renal cell carcinoma (RCC) is one of the most lethal urological cancers,
highly resistant to chemo and radiotherapy. Obesity and smoking are the
best-known risk factors of RCC, both related to oxidative stress
presence, suggesting a significant role in RCC development and
maintenance. Surgical resection is the treatment of choice for localized
RCC; however, this neoplasia is hardly diagnosable at its initial
stages, occurring commonly in late phases and even when metastasis is
already present. Systemic therapies are the option against RCC in these
more advanced stages, such as cytokine therapy or a combination of
tyrosine kinase inhibitors with immunotherapies; nevertheless, these
strategies are still insufficient. A field poorly analyzed in this
neoplasia is the status of cell signaling pathways sensible to the redox
state, which have been associated with the development and maintenance
of RCC. This review focuses on alterations reported in the following
redox-sensitive molecules and signaling pathways in RCC:
mitogen-activated protein kinases, protein kinase B (AKT)/tuberous
sclerosis complex 2/mammalian target of rapamycin C1, AKT/glycogen
synthase kinase 3/beta-catenin, nuclear factor kappa B/inhibitor of
kappa B/epidermal growth factor receptor, and protein kinase C
zeta/cut-like homeodomain protein/factor inhibiting hypoxia-inducible
factor (HIF)/HIF as potential targets for redox therapy.
Filiaciones:
Cruz-Gregorio, Alfredo:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Lab F225, Ciudad De Mexico 04510, Mexico
Karina Aranda-Rivera, Ana:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Lab F315, Ciudad De Mexico, Mexico
Pedraza-Chaverri, Jose:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Lab F315, Ciudad De Mexico, Mexico
Solano, Jose D.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Lab F225, Ciudad De Mexico 04510, Mexico
Elena Ibarra-Rubio, Maria:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Lab F225, Ciudad De Mexico 04510, Mexico
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