DNA, a target of mixed chelate copper(II) compounds (Casiopeinas (R)) studied by electrophoresis, UV-vis and circular dichroism techniques.
Por:
Figueroa-DePaz, Yeshenia, Resendiz-Acevedo, Karen, Davila-Manzanilla, Silvia Graciela, Garcia-Ramos, Juan Carlos, Ortiz-Frade, Luis, Serment-Guerrero, Jorge, Ruiz-Azuara, Lena
Publicada:
1 jun 2022
Resumen:
Casiopeinas are a family of mixed chelate copper(II) complexes with
antiproliferative and antineoplastic activities, results that have
positioned them as an alternative for cancer treatment. Because DNA is
one of their principal targets, it is of our interest to find out the
effect of substituents on the diiamine ligands over mode of interaction.
Therefore, we studied 21 Casiopeinas upon DNA by gel electrophoresis,
UV-vis and circular dichroism (CD) spectroscopic techniques, previously
studied by DFT calculations and Quantitative Structure Activity
Relationship (QSAR). According to electrophoresis results, the
interaction modes between Casiopeinas with DNA may be through the
intercalation or in the minor groove. UV-vis spectroscopy showed a
hypochromic or hyperchromic effect as a consequence of each interaction.
The analysis suggests the binding along the minor groove and
intercalation are both influenced by the substituents in the diimine
ligands and depend on the nature of the secondary moiety
(acetylacetonate or glycinate). Additionally, a new band in
electrophoresis and CD spectra suggests adducts formation. In general,
we prove that molecules with the highest molecular weight, electron
donating substituents and glycinate as secondary ligand are
intercalating agents; unlike molecules with electron withdrawing
substituents as chloride or nitro and acetylacetonate as secondary
ligand which interact in the minor groove.
Filiaciones:
Figueroa-DePaz, Yeshenia:
Departamento de Química Inorgánica y Nuclear, Facultad de Química, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad de México, CP 04510, Mexico
Univ Nacl Autonoma Mexico, Dept Quim Inorgan & Nucl, Fac Quim, Ave Univ 3000, Mexico City 04510, Mexico
Resendiz-Acevedo, Karen:
Departamento de Química Inorgánica y Nuclear, Facultad de Química, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad de México, CP 04510, Mexico
Univ Nacl Autonoma Mexico, Dept Quim Inorgan & Nucl, Fac Quim, Ave Univ 3000, Mexico City 04510, Mexico
Davila-Manzanilla, Silvia Graciela:
Departamento de Química Inorgánica y Nuclear, Facultad de Química, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad de México, CP 04510, Mexico
Univ Nacl Autonoma Mexico, Dept Quim Inorgan & Nucl, Fac Quim, Ave Univ 3000, Mexico City 04510, Mexico
Garcia-Ramos, Juan Carlos:
Departamento de Química Inorgánica y Nuclear, Facultad de Química, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad de México, CP 04510, Mexico
Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Blvd. Zertuche y Blvd. De los Lagos S/N Fracc. Valle Dorado, Ensenada, 22890, Mexico
Univ Nacl Autonoma Mexico, Dept Quim Inorgan & Nucl, Fac Quim, Ave Univ 3000, Mexico City 04510, Mexico
Univ Autonoma Baja Calif, Escuela Ciencias Salud, Blvd Zertuche & Blvd Lagos S-N Fracc Valle Dorado, Ensenada 22890, Mexico
Ortiz-Frade, Luis:
Departamento de Electroquímica, Centro de Investigación y Desarrollo Tecnológico en Electroquímica S.C. Parque Tecnológico Querétaro, Sanfandila, Pedro de Escobedo, Querétaro, CP 76703, Mexico
Ctr Invest & Desarrollo Tecnol Electroquim, Dept Electroquim, SC Parque Tecnol Queretaro,Sanfandila, Pedro de Escobedo 76703, Queretaro, Mexico
Serment-Guerrero, Jorge:
Departamento de Biología, Instituto Nacional de Investigaciones Nucleares, Carretera Mexico, Toluca S/N, La Marquesa, Ocoyoacac, Mexico
Inst Nacl Invest Nucl, Dept Biol, Carretera Mexico,Toluca S-N, La Marquesa, Mexico
Ruiz-Azuara, Lena:
Departamento de Química Inorgánica y Nuclear, Facultad de Química, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad de México, CP 04510, Mexico
Univ Nacl Autonoma Mexico, Dept Quim Inorgan & Nucl, Fac Quim, Ave Univ 3000, Mexico City 04510, Mexico
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