Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranes
Por:
Martinez, Jose L., Eichwald, Catherine, Schraner, Elisabeth M., Lopez, Susana, Arias, Carlos F.
Publicada:
1 abr 2022
Categoría:
Virology
Resumen:
Rotavirus (RV) replication occurs in cytoplasmic membrane-less,
electron-dense inclusions termed viroplasms, composed of viral and
cellular elements. These inclusions have been shown to colocalize with
components of the lipid droplets (LDs), unique organelles that play an
essential role in lipid metabolism. Given the robust LDs-viroplasm
association, LDs have been proposed to serve as a scaffold for viroplasm
assembly. Interestingly, no evidence has described the participation of
lipid metabolism in other RV replication steps. Here, we report that
lipid metabolism is essential to maintain the production of the
infectious virus through a process independent of viroplasm biogenesis.
Disruption of the lipogenesis-lipolysis balance dissociates endoplasmic
reticulum mem-branes from viroplasms, suggesting that lipid metabolism
is essential for a continuous flux of lipids to allow the association
between viroplasms and ER membranes. LDs could also be relevant as lipid
reservoirs for membrane synthesis required to form mature infectious
rotavirus particles.
Filiaciones:
Martinez, Jose L.:
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Morelos, Cuernavaca, Mexico
Eichwald, Catherine:
Institute of Virology, University of Zurich, Zurich, Switzerland
Schraner, Elisabeth M.:
Institute of Virology, University of Zurich, Zurich, Switzerland
Lopez, Susana:
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Morelos, Cuernavaca, Mexico
Arias, Carlos F.:
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Morelos, Cuernavaca, Mexico
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