Determination of zilpaterol in a residue depletion study using LC-MS/MS in cattle plasma, muscle, liver and kidney
Por:
Dolores-Hernandez, Mariana, Morales-Hipolito, Elvia A. A., Villaseñor A., Lopez-Arellano, Raquel
Publicada:
15 jul 2022
Resumen:
Zilpaterol is a 8-agonist compound which promotes fat loss and muscle
gain in cattle, providing economic benefits. However, zilpaterol
residues in the animal might introduce a significant risk to humans
after consumption. In the present manuscript, a highly specific,
sensitive method using Selected Reaction Monitoring (SRM) in positive
electrospray ionization (ESI +) mode by liquid chromatography coupled to
triple quadrupole mass spectrometry (LC-MS/MS) for plasma, muscle, liver
and kidney is presented. For method development, composition of the
aqueous mobile phase, precipitation agent, and solid phase extraction
(SPE) conditions were optimized. The method was fully validated showing
a good linearity and recovery average greater than or equal to 97 % for
all matrices. The method was applied to residue depletion studies in
cattle after withdrawal of zilpaterol supplementation at 3, 4, 5 and 6
days showing that tissues can be consumed by humans after 4th day of
zilpaterol withdrawal.
Filiaciones:
Dolores-Hernandez, Mariana:
Laboratory of Pharmaceutical Development Tests, Multidisciplinary Research Unit (UIM), Faculty of Higher Education Cuautitlán, National Autonomous University of Mexico, Carr. Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, Cuautitlán Izcalli, 54714, Mexico
Univ Nacl Autonoma Mexico, Fac Higher Educ Cuautitlan, Multidisciplinary Res Unit UIM, Lab Pharmaceut Dev Tests, Carr Cuautitlan Teoloyucan Km 2-5, Cuautitlan 54714, Mexico
Morales-Hipolito, Elvia A. A.:
Laboratory of Pharmaceutical Development Tests, Multidisciplinary Research Unit (UIM), Faculty of Higher Education Cuautitlán, National Autonomous University of Mexico, Carr. Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, Cuautitlán Izcalli, 54714, Mexico
Univ Nacl Autonoma Mexico, Fac Higher Educ Cuautitlan, Multidisciplinary Res Unit UIM, Lab Pharmaceut Dev Tests, Carr Cuautitlan Teoloyucan Km 2-5, Cuautitlan 54714, Mexico
Villaseñor A.:
IMMA, Instituto de Medicina Molecular Aplicada, Facultad de Medicina, San Pablo CEU Universities, Madrid, Spain
Lopez-Arellano, Raquel:
Laboratory of Pharmaceutical Development Tests, Multidisciplinary Research Unit (UIM), Faculty of Higher Education Cuautitlán, National Autonomous University of Mexico, Carr. Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, Cuautitlán Izcalli, 54714, Mexico
Univ Nacl Autonoma Mexico, Fac Higher Educ Cuautitlan, Multidisciplinary Res Unit UIM, Lab Pharmaceut Dev Tests, Carr Cuautitlan Teoloyucan Km 2-5, Cuautitlan 54714, Mexico
San Pablo CEU Univ, Fac Med, IMMA, Inst Med Mol Aplicada, Madrid, Spain
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