Populations, Traits, and Their Spatial Structure in Humans
Por:
Sohail, Mashaal, Izarraras-Gomez, Alan, Ortega-Del Vecchyo, Diego
Publicada:
1 ene 2021
Resumen:
The spatial distribution of genetic variants is jointly determined by geography, past demographic processes, natural selection, and its interplay with environmental variation. A fraction of these genetic variants are "causal alleles" that affect the manifestation of a complex trait. The effect exerted by these causal alleles on complex traits can be independent or dependent on the environment. Understanding the evolutionary processes that shape the spatial structure of causal alleles is key to comprehend the spatial distribution of complex traits. Natural selection, past population size changes, range expansions, consanguinity, assortative mating, archaic introgression, admixture, and the environment can alter the frequencies, effect sizes, and heterozygosities of causal alleles. This provides a genetic axis along which complex traits can vary. However, complex traits also vary along biogeographical and sociocultural axes which are often correlated with genetic axes in complex ways. The purpose of this review is to consider these genetic and environmental axes in concert and examine the ways they can help us decipher the variation in complex traits that is visible in humans today. This initiative necessarily implies a discussion of populations, traits, the ability to infer and interpret "genetic" components of complex traits, and how these have been impacted by adaptive events. In this review, we provide a history-aware discussion on these topics using both the recent and more distant past of our academic discipline and its relevant contexts. © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Filiaciones:
Sohail, Mashaal:
Department of Human Genetics, University of Chicago, United States
Centro de Ciencias Genómicas (CCG), Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico
Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA
Univ Nacl Autonoma Mexico, Ctr Ciencias Genom CCG, Cuernavaca, Morelos, Mexico
Izarraras-Gomez, Alan:
Laboratorio Internacional de Investigación sobre el Genoma Humano (LIIGH), Universidad Nacional Autónoma de México (UNAM), Juriquilla, Querétaro, Mexico
Univ Nacl Autonoma Mexico, Lab Int Invest Genoma Humano LIIGH, Juriquilla, Queretaro, Mexico
Ortega-Del Vecchyo, Diego:
Laboratorio Internacional de Investigación sobre el Genoma Humano (LIIGH), Universidad Nacional Autónoma de México (UNAM), Juriquilla, Querétaro, Mexico
Univ Nacl Autonoma Mexico, Lab Int Invest Genoma Humano LIIGH, Juriquilla, Queretaro, Mexico
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