Cellular Senescence and ApoE4: Their Repercussions in Alzheimer's Disease


Por: Tecalco-Cruz, Angeles C., Zepeda-Cervantes, Jesus, Lopez-Canovas, Lilia, Oriando Ramirez-Jarquin, Josue, Pedraza-Chaverri, Jose, Briones-Herrera, Alfredo

Publicada: 1 nov 2021
Resumen:
Alzheimer's Disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE epsilon 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implications of cellular senescence and the ApoE variants in AD. Molecular studies of these risk factors for AD may hence be pivotal to define new biomarkers and novel therapeutic strategies for this neurodegenerative pathology.

Filiaciones:
Tecalco-Cruz, Angeles C.:
 Univ Autonoma Ciudad Mexico UACM, Ciencias Genom, Ciudad De Mexico 03100, Mexico

Zepeda-Cervantes, Jesus:
 Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Ciudad De Mexico 04510, Mexico

Lopez-Canovas, Lilia:
 Univ Autonoma Ciudad Mexico UACM, Ciencias Genom, Ciudad De Mexico 03100, Mexico

Oriando Ramirez-Jarquin, Josue:
 Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Ciudad De Mexico 04510, Mexico

Pedraza-Chaverri, Jose:
 Univ Nacl Autonoma Mexico, Fac Quim, Ciudad De Mexico 04510, Mexico

Briones-Herrera, Alfredo:
 Univ Nacl Autonoma Mexico, Fac Quim, Ciudad De Mexico 04510, Mexico
ISSN: 18715273





CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Editorial
Bentham Science Publishers B.V., 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND, Países Bajos
Tipo de documento: Review
Volumen: 20 Número: 9
Páginas: 778-785
WOS Id: 000730038400001
ID de PubMed: 34182916

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