Cellular Senescence and ApoE4: Their Repercussions in Alzheimer's Disease
Por:
Tecalco-Cruz, Angeles C., Zepeda-Cervantes, Jesus, Lopez-Canovas, Lilia, Oriando Ramirez-Jarquin, Josue, Pedraza-Chaverri, Jose, Briones-Herrera, Alfredo
Publicada:
1 nov 2021
Resumen:
Alzheimer's Disease (AD) is characterized by progressive memory loss due
to neurodegeneration that occurs mainly during aging. The accumulation
of senescent cells has been related to aging. Furthermore, the
expression of the variant ApoE epsilon 4 is a critical risk factor for
AD. Some events that occur in senescence, such as the secretion of
pro-inflammatory molecules, and metabolic and epigenetic changes, in
addition to the detection of ApoE4, may accelerate the progression of
AD. Here, we discuss the implications of cellular senescence and the
ApoE variants in AD. Molecular studies of these risk factors for AD may
hence be pivotal to define new biomarkers and novel therapeutic
strategies for this neurodegenerative pathology.
Filiaciones:
Tecalco-Cruz, Angeles C.:
Univ Autonoma Ciudad Mexico UACM, Ciencias Genom, Ciudad De Mexico 03100, Mexico
Zepeda-Cervantes, Jesus:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Ciudad De Mexico 04510, Mexico
Lopez-Canovas, Lilia:
Univ Autonoma Ciudad Mexico UACM, Ciencias Genom, Ciudad De Mexico 03100, Mexico
Oriando Ramirez-Jarquin, Josue:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Ciudad De Mexico 04510, Mexico
Pedraza-Chaverri, Jose:
Univ Nacl Autonoma Mexico, Fac Quim, Ciudad De Mexico 04510, Mexico
Briones-Herrera, Alfredo:
Univ Nacl Autonoma Mexico, Fac Quim, Ciudad De Mexico 04510, Mexico
|