Identification of profiles of volatile organic compounds in exhaled breath by means of an electronic nose as a proposal for a screening method for breast cancer: A case-control study
Por:
De León-Martínez L.D., Rodríguez-Aguilar M., Gorocica-Rosete P., Domínguez-Reyes C.A., Martínez-Bustos V., Tenorio-Torres J.A., Ornelas-Rebolledo O., Cruz-Ramos J.A., Balderas-Segura B., Flores-Ramírez R.
Publicada:
1 ene 2020
Categoría:
Pulmonary and respiratory medicine
Resumen:
The objective of the present study was to identify volatile prints from exhaled breath, termed breath-print, from breast cancer (BC) patients and healthy women by means of an electronic nose and to evaluate its potential use as a screening method. A cross-sectional study was performed on 443 exhaled breath samples from women, of whom 262 had been diagnosed with BC by biopsy and 181 were healthy women (control group). Breath-print analysis was performed utilizing the Cyranose 320 electronic nose. Group data were evaluated by principal component analysis (PCA), canonical discriminant analysis (CDA), and support vector machine (SVM), and the test's diagnostic power was evaluated by means of receiver operating characteristic (ROC) curves. The results obtained using the model generated from the CDA, which best describes the behavior of the assessed groups, indicated that the breath-print of BC patients was different from that of healthy women and that they presented with a variability of up to 98.8% and a correct classification of 98%. The sensitivity, specificity, negative predictive value, and positive predictive value reached 100% according to the ROC curve. The present study demonstrates the capability of the electronic nose to separate between healthy subjects and BC patients. This research could have a beneficial impact on clinical practice as we consider that this test could probably be used at the first point before the application of established gold tests (mammography, ultrasound, and biopsy) and substantially improve screening tests in the general population. © 2020 The Author(s).
Filiaciones:
De León-Martínez L.D.:
Center for Applied Research in Environment and Health, CIACYT, Medicine Faculty, Autonomous University of San Luis Potosí, Av. Venustiano Carranza 2405, San Luis Potosí, SLP, CP 78210, Mexico
Rodríguez-Aguilar M.:
Center for Applied Research in Environment and Health, CIACYT, Medicine Faculty, Autonomous University of San Luis Potosí, Av. Venustiano Carranza 2405, San Luis Potosí, SLP, CP 78210, Mexico
Gorocica-Rosete P.:
Biochemestry Research Department of National Institute Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico
Domínguez-Reyes C.A.:
Fundación del Cáncer de Mama A.C., Mexico city, Mexico
Martínez-Bustos V.:
Fundación del Cáncer de Mama A.C., Mexico city, Mexico
Tenorio-Torres J.A.:
Fundación del Cáncer de Mama A.C., Mexico city, Mexico
Ornelas-Rebolledo O.:
Labinnova Center of Investigation in Breath for early detection diseases, Guadalajara, Mexico
Cruz-Ramos J.A.:
Instituto Jalisciense de Cancerología, Guadalajara, Mexico
Balderas-Segura B.:
Biochemestry Research Department of National Institute Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico
Flores-Ramírez R.:
CONACYT Research Fellow, Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona No. 550, Colonia Lomas Segunda Sección, San Luis Potosí, SLP, CP 78210, Mexico
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