Evaluation of Panbio rapid antigen test for SARS-CoV-2 in symptomatic patients and their contacts: a multicenter study
Por:
Thirion-Romero, Ireri, Guerrero-Zuniga, Selene, Arias-Mendoza, Alexandra, Patricia Cornejo-Juarez, Dora, Meza-Meneses, Patricia, Stalin Torres-Erazo, Darwin, Hernandez-Gilsoul, Thierry, Galindo-Fraga, Arturo, Villegas-Mota, Isabel, Sepulveda-Delgado, Jesus, Avila-Rios, Santiago, Becerril-Vargas, Eduardo, Fernandez-Plata, Rosario, Midori Perez-Kawabe, Tit, Coeto-Cano, Ana, Armando Vazquez-Perez, Joel, Kawa-Karasik, Simon, Reyes-Teran, Gustavo, Rogelio Perez-Padilla, Jose
Publicada:
1 dic 2021
Resumen:
Background: Point-of-care rapid tests to identify SARS-CoV-2 can have
clinical benefits. Methods: A cross-sectional study in adults visiting
emergency services or screening sites of referral hospitals for COVID-19
to validate the diagnostic performance of a rapid antigen test for
SARS-CoV-2 (Abbott's Panbio) compared with reverse
transcription-polymerase chain reaction (RT-PCR) testing. Tests were
performed by health personnel in a routine situation during a COVID-19
outbreak. Results: A total of 1060 participants (mean age 47, 46% with
a self-reported comorbidity) were recruited from 8 hospitals in Mexico.
Participants provided 1060 valid Panbio rapid test-RT-PCR test pairs
with 45% testing positive in the RT-PCR. Overall sensitivity of the
Panbio test was 54.2% (95% CI 51%-57%), and 69.1% (95% CI
66%-73%) for patients during the first week of symptoms. Sensitivity
depended on viral load (cycle threshold (Ct) of RT-PCR) and days of
symptoms. With a Ct <= 25, sensitivity was 82% (95% CI, 76%-87%).
Specificity of the Panbio test was > 97.8% in all groups. Conclusions:
The Panbio rapid antigen test for SARS-CoV-2 had good specificity but
low sensitivity. A negative test requires confirmation with RT-PCR,
especially for testing after the first week of symptoms. (c) 2021 The
Author(s). Published by Elsevier Ltd on behalf of International Society
for Infectious Diseases. This is an open access article under the CC
BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
Filiaciones:
Thirion-Romero, Ireri:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
Guerrero-Zuniga, Selene:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
Arias-Mendoza, Alexandra:
Inst Nacl Cardiol Ignacio Chavez, Ciudad De Mexico, Mexico
Patricia Cornejo-Juarez, Dora:
Inst Nacl Cancerol, Ciudad De Mexico, Mexico
Meza-Meneses, Patricia:
Hosp Reg Alta Especialidad Ixtapaluca, Ixtapaluca, Estado De Mexic, Mexico
Stalin Torres-Erazo, Darwin:
Hosp Reg Alta Especialidad Peninsula Yucatan, Merida, Estado De Yucat, Mexico
Hernandez-Gilsoul, Thierry:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Ciudad De Mexico, Mexico
Galindo-Fraga, Arturo:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Ciudad De Mexico, Mexico
Villegas-Mota, Isabel:
Inst Nacl Perinatol, Ciudad De Mexico, Mexico
Sepulveda-Delgado, Jesus:
Hosp Reg Alta Especialidad Ciudad Salud Tapachula, Los Toros, Estado De Chiap, Mexico
Avila-Rios, Santiago:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
Becerril-Vargas, Eduardo:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
Fernandez-Plata, Rosario:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
Midori Perez-Kawabe, Tit:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
Coeto-Cano, Ana:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
Armando Vazquez-Perez, Joel:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
Kawa-Karasik, Simon:
Coordinac Inst Nacl Salud & Hosp Reg Alta Especia, Ciudad De Mexico, Mexico
Reyes-Teran, Gustavo:
Coordinac Inst Nacl Salud & Hosp Reg Alta Especia, Ciudad De Mexico, Mexico
Rogelio Perez-Padilla, Jose:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico
gold, Green Published
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