Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results
Por:
Ruiz-Garcia, Erika, Pena-Nieves, Adriana, Alegria-Banos, Jorge, Cornejo-Juarez, Patricia, Meneses-Garcia, Abelardo, Rivera Rivera, Samuel, Jose Sanchez, Juan, Gerson-Cwilich, Raquel, Shveid Gerson, Daniela, Medina Franco, Heriberto, Alejandra Buerba, Gabriela, Acosta Espinoza, Alicia, Valencia Mijares, Norma, Fernandez-Figueroa, Edith A., Vazquez, Roberto A., Vilar-Compte, Diana, De la Rosa Martinez, Daniel, Valdez-Reyes, Melissa, Martinez Sanchez, Yazmin, Moises Tavera, Diego, Viveros Aguilar, Eloina, Camarin, Efrain, Villegas, Diana, Noguez, Alejandro, Ortiz Brizuela, Edgar, Mendez-Calderillo, Viridiana, Pacheco Perez, Rodrigo, Feregrino Arreola, Juan Pablo, Burguete Torres, Alan, Vidal Gutierrez, Oscar, Anorve Bailon, Denisse, Castillo Gutierrez, Erika, Luna Merlos, Pedro, Rivera Marquez, Raul, Jimenez Lopez, Jose Carlos, del Castillo Balderas, Gabriela Alvarez, ONCOVID-MEX Grp
Publicada:
1 sep 2021
Categoría:
Medicine (miscellaneous)
Resumen:
Purpose: The aim of this study was to evaluate the demographic
characteristics, clinical and pathological factors, and the outcome of
cancer and COVID-19 patients in Mexico.
Patients and methods: A prospective, multicentric study was performed
through a digital platform to have a national registry of patients with
cancer and positive SARS-CoV-2 test results through reverse
transcription quantitative polymerase chain reaction (RT-qPCR). We
performed the analysis through a multivariate logistic regression model
and Cox proportional hazard model.
Results: From May to December 2020, 599 patients were registered with an
average age of 56 years with 59.3% female; 27.2% had hypertension. The
most frequent diagnoses were breast cancer (30.4%), lymphoma (14.7%),
and colorectal cancer (14.0%); 72.1% of patients had active cancer and
23.5% of patients (141/599) were deceased, the majority of which were
men (51.7%). This study found that the prognostic factors that reduced
the odds of death were gender (OR = 0.42, p = 0.031) and oxygen
saturation (OR = 0.90, p = 0.0001); meanwhile, poor ECOG (OR = 5.4, p =
0.0001), active disease (OR = 3.9, p = 0.041), dyspnea (OR = 2.5, p =
0.027), and nausea (OR = 4.0, p = 0.028) increased the odds of death. In
the meantime, the factors that reduce survival time were age (HR = 1.36,
p = 0.035), COPD (HR = 8.30, p = 0.004), having palliative treatment (HR
= 10.70, p = 0.002), and active cancer without treatment (HR = 8.68, p =
0.008).
Conclusion: Mortality in cancer patients with COVID-19 is determined by
prognostic factors whose identification is necessary. In our cancer
population, we have observed that being female, younger, non-COPD, with
non-active cancer, good performance status, and high oxygen levels
reduce the probability of death.
Filiaciones:
Ruiz-Garcia, Erika:
Inst Nacl Cancerol, Dept Med Oncol, Av San Fernando 22, Mexico City 14080, DF, Mexico
Inst Nacl Cancerol, Translat Med Lab, Av San Fernando 22, Mexico City 14080, DF, Mexico
Pena-Nieves, Adriana:
Inst Nacl Cancerol, Translat Med Lab, Av San Fernando 22, Mexico City 14080, DF, Mexico
Alegria-Banos, Jorge:
Ctr Oncol Hosp Med Sur, Mexico City, DF, Mexico
Univ La Salle, Fac Ciencias Quim, Mexico City, DF, Mexico
Cornejo-Juarez, Patricia:
Inst Nacl Cancerol, Dept Infect Dis, Av San Fernando 22, Mexico City 14080, DF, Mexico
Meneses-Garcia, Abelardo:
Inst Nacl Cancerol, Translat Med Lab, Av San Fernando 22, Mexico City 14080, DF, Mexico
Rivera Rivera, Samuel:
IMSS, Dept Med Oncol, Hosp Oncol CM SXXI, Mexico City, DF, Mexico
Jose Sanchez, Juan:
IMSS, Dept Med Oncol, Hosp Oncol CM SXXI, Mexico City, DF, Mexico
Gerson-Cwilich, Raquel:
Ctr Med ABC, Dept Med Oncol, Mexico City, DF, Mexico
Shveid Gerson, Daniela:
Ctr Med ABC, Dept Med Oncol, Mexico City, DF, Mexico
Medina Franco, Heriberto:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Surg, Mexico City, DF, Mexico
Alejandra Buerba, Gabriela:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Surg, Mexico City, DF, Mexico
Acosta Espinoza, Alicia:
Hosp ISSSTE ISSSTECALI, Mexicali, Baja California, Mexico
Valencia Mijares, Norma:
IMSS, Hosp Reg Alta Especialidad Oaxaca, UMAA 1, Oaxaca, Oaxaca, Mexico
Fernandez-Figueroa, Edith A.:
Inst Nacl Med Genom, Computat & Integrat Genom, Mexico City, DF, Mexico
Vazquez, Roberto A.:
Univ La Salle, Fac Ingn, Mexico City, DF, Mexico
Vilar-Compte, Diana:
Inst Nacl Cancerol, Dept Infect Dis, Av San Fernando 22, Mexico City 14080, DF, Mexico
Inst Nacl Cancerol, Hosp Epidemiol, Mexico City, DF, Mexico
De la Rosa Martinez, Daniel:
Univ Nacl Autonoma Mexico, Fac Med, Plan Estudios Combinados Med PECEM, Mexico City, DF, Mexico
Valdez-Reyes, Melissa:
Inst Nacl Cancerol, Translat Med Lab, Av San Fernando 22, Mexico City 14080, DF, Mexico
Martinez Sanchez, Yazmin:
IMSS, Hosp Epidemiol, Hosp Oncol CM SXXI, Mexico City, DF, Mexico
Moises Tavera, Diego:
IMSS, Hosp Epidemiol, Hosp Oncol CM SXXI, Mexico City, DF, Mexico
Viveros Aguilar, Eloina:
IMSS, Dept Med Oncol, Hosp Oncol CM SXXI, Mexico City, DF, Mexico
Camarin, Efrain:
Ctr Med ABC, Dept Med Oncol, Mexico City, DF, Mexico
Villegas, Diana:
Ctr Med ABC, Dept Med Oncol, Mexico City, DF, Mexico
Noguez, Alejandro:
Ctr Med ABC, Dept Med Oncol, Mexico City, DF, Mexico
Ortiz Brizuela, Edgar:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Infect Dis, Mexico City, DF, Mexico
Mendez-Calderillo, Viridiana:
Hosp Med Celaya, Guanajuato, Mexico
Pacheco Perez, Rodrigo:
Hosp Reg ISSSTE, Merida, Yucatan, Mexico
Feregrino Arreola, Juan Pablo:
Hosp H Queretaro, Queretaro, Mexico
Burguete Torres, Alan:
Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose E Gonzalez, San Nicolas De Los Garza, Nuevo Leon, Mexico
Vidal Gutierrez, Oscar:
Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose E Gonzalez, San Nicolas De Los Garza, Nuevo Leon, Mexico
Anorve Bailon, Denisse:
ISSSTE, Hosp Reg Gen Ignacio Zaragoza, Mexico City, DF, Mexico
Castillo Gutierrez, Erika:
CMN Adolfo Ruiz Cortines Veracruz, UMAE Hosp Especialidades 14, Veracruz, Veracruz, Mexico
Luna Merlos, Pedro:
Ctr Oncol Hosp Med Sur, Mexico City, DF, Mexico
Rivera Marquez, Raul:
Hosp Gen Reg 1 IMSS, Obregon, Sonora, Mexico
Jimenez Lopez, Jose Carlos:
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City, DF, Mexico
del Castillo Balderas, Gabriela Alvarez:
Univ La Salle, Fac Ingn, Mexico City, DF, Mexico
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