Regulation of Metabolic Health by an ``Olfactory-Hypothalamic Axis'' and Its Possible Implications for the Development of Therapeutic Approaches for Obesity and T2D
Por:
Guzman-Ruiz, Mara Alaide, Jimenez, Adriana, Cardenas-Rivera, Alfredo, Guerrero-Vargas, Natali N., Organista-Juarez, Diana, Guevara-Guzman, Rosalinda
Publicada:
1 ago 2022
Ahead of Print:
1 abr 2021
Resumen:
The olfactory system is responsible for the reception, integration and
interpretation of odors. However, in the last years, it has been
discovered that the olfactory perception of food can rapidly modulate
the activity of hypothalamic neurons involved in the regulation of
energy balance. Conversely, the hormonal signals derived from changes in
the metabolic status of the body can also change the sensitivity of the
olfactory system, suggesting that the bidirectional relationship
established between the olfactory and the hypothalamic systems is key
for the maintenance of metabolic homeostasis. In the first part of this
review, we describe the possible mechanisms and anatomical pathways
involved in the modulation of energy balance regulated by the olfactory
system. Hence, we propose a model to explain its implication in the
maintenance of the metabolic homeostasis of the organism. In the second
part, we discuss how the olfactory system could be involved in the
development of metabolic diseases such as obesity and type two diabetes
and, finally, we propose the use of intranasal therapies aimed to
regulate and improve the activity of the olfactory system that in turn
will be able to control the neuronal activity of hypothalamic centers to
prevent or ameliorate metabolic diseases.
Filiaciones:
Guzman-Ruiz, Mara Alaide:
Laboratorio Sensorial, Departamento de Fisiología, Facultad de Medicina, Edificio A, 4º piso, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04510, Mexico
Jimenez, Adriana:
Laboratorio Sensorial, Departamento de Fisiología, Facultad de Medicina, Edificio A, 4º piso, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04510, Mexico
Cardenas-Rivera, Alfredo:
Centro de Investigación en Bioingeniería, Universidad de Ingeniería y Tecnología, Lima, Peru
Guerrero-Vargas, Natali N.:
Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico
Organista-Juarez, Diana:
Laboratorio Sensorial, Departamento de Fisiología, Facultad de Medicina, Edificio A, 4º piso, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04510, Mexico
Guevara-Guzman, Rosalinda:
Laboratorio Sensorial, Departamento de Fisiología, Facultad de Medicina, Edificio A, 4º piso, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04510, Mexico
|