Glicocalix en sepsis
Por:
Godinez-Vidal A.R., Carrillo-Esper R., Cabello-Aguilera R.
Publicada:
1 ene 2021
Categoría:
Internal medicine
Resumen:
Glycocalyx is structurally conformed by glycoproteins and glycosaminoglycans. It constitutes a layer covering the vascular endothelium and is the interface among blood flow, endothelial cell and interstice. Glycocalyx is essential to maintain the integrity of the endothelial function. The fragments of glycocalyx released into the blood during sepsis can serve as clinically relevant biomarkers, given the pathophysiological implications of their degradation, it is also believed that the degradation contributes to the dysfunction of the microcirculation in sepsis. This paper reviews the current concepts related to the degradation of glycocalyx and its impact on sepsis. © 2021 Comunicaciones Cientificas Mexicanas S.A. de C.V.. All rights reserved.
Filiaciones:
Godinez-Vidal A.R.:
Departamento de Cirugía General, Mexico
Carrillo-Esper R.:
Departamento de Terapia Intensiva, Mexico
Cabello-Aguilera R.:
Hospital HMG Coyoacán, Ciudad de México, Mexico