Cutaneous Manifestations Related to COVID-19 Immune Dysregulation in the Pediatric Age Group


Por: Larenas-Linnemann D., Luna-Pech J., Navarrete-Rodríguez E.M., Rodríguez-Pérez N., Arias-Cruz A., Blandón-Vijil M.V., Del Rio-Navarro B.E., Estrada-Cardona A., Onuma-Takane E., Pozo-Beltrán C.F., Valencia-Herrera A.M., Ortiz-Aldana F.I., Toledo-Bahena M.E.

Publicada: 1 ene 2021
Resumen:
Purpose of Review: At the juncture of the COVID-19 pandemic, the world is currently in an early phase of collecting clinical data and reports of its skin manifestations, and its pathophysiology is still highly conjectural. We reviewed cutaneous manifestations associated with COVID-19 in the pediatric age group. Recent Findings: Children infected by SARS-CoV-2 usually develop milder respiratory symptoms, but cutaneous manifestations seem a little more prevalent than in adults. These skin features of infection by the coronavirus can be similar to those produced by other common viruses, but there are also reports of cases with more heterogeneous clinical pictures, which have made their classification difficult. To date, the more frequently reported skin variants featured in pediatric cases are purpuric (pseudo-chilblain, necrotic-acral ischemia, hemorrhagic macules, and/or cutaneous necrosis), morbilliform/maculopapular, erythema multiforme, urticarial, vesicular, Kawasaki-like, and miscellaneous (highly variable in both frequency and severity). Their pathophysiological mechanism is still elusive and is likely to be the result of the complex involvement of one or more mechanisms, like direct virus-induced skin damage, vasculitis-like reactions, and/or indirect injury as a consequence of a systemic inflammatory reaction. Summary: In this review, we presented and discussed clinical cases as examples of different cutaneous responses reported in some children with SARS-CoV-2 infection, differential diagnosis considerations, and a preliminary conceptual approach to some of their probable associated pathologic mechanisms. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Filiaciones:
Larenas-Linnemann D.:
 Médica Sur Fundación Clínica y Hospital, Mexico City, Mexico

 Hospital Médica Sur, Torre 2, cons. Puente de piedra 150, T2-602 Toriello-Guerra

Luna-Pech J.:
 Departamento de Disciplinas Filosóficas Metodoloógicas e Instrumentales, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Navarrete-Rodríguez E.M.:
 Servicio de Alergia e Inmunología Clínica, Hospital Infantil de Mexico Federico Gómez, Mexico City, Mexico

Rodríguez-Pérez N.:
 Consulta Privada, Universidad Autónoma de Tamaulipas, Matamoros, Tamaulipas, Mexico

Arias-Cruz A.:
 Facultad de Medicina y Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico

Blandón-Vijil M.V.:
 Consulta Privada, Hospital Médica Sur, Mexico City,, Mexico

Del Rio-Navarro B.E.:
 Servicio de Alergia e Inmunología Clínica, Hospital Infantil de Mexico Federico Gómez, Mexico City, Mexico

Estrada-Cardona A.:
 Consulta Privada, Grupo COSTAMED, Playa del Carmen, Quintana Roo, Mexico

Onuma-Takane E.:
 Consulta Privada, Hospital Médica Sur, Mexico City,, Mexico

Pozo-Beltrán C.F.:
 Subdirección de Enseñanza e Investigación, Hospital General de Especialidades Juan María Salvatierra, La Paz, Baja California Sur, Mexico

Valencia-Herrera A.M.:
 Servicio de Dermatología, Hospital Infantil de Mexico Federico Gómez, Mexico City, Mexico

Ortiz-Aldana F.I.:
 ALERGO-ASMA de México, Irapuato, Guanajuato, Mexico

Toledo-Bahena M.E.:
 Servicio de Dermatología, Hospital Infantil de Mexico Federico Gómez, Mexico City, Mexico
ISSN: 15297322
Editorial
Current Science Inc., Estados Unidos America
Tipo de documento: Review
Volumen: 21 Número: 2
Páginas:
WOS Id: 000621820900001
ID de PubMed: 33630167
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