The Immune System and Viral Hepatitis
Por:
Fierro N.A., Gonzalez-Aldaco K., Roman S., Panduro A.
Publicada:
1 ene 2017
Resumen:
Hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis E virus are viruses with hepatotropic lifecycles. Numerous studies have demonstrated the prominent role of the immune system in liver damage caused by these viruses. This chapter introduces the concept that differences in the host immune response dictate the distinct outcomes to these infections. It starts by presenting the natural history of these viral illnesses. A high-level perspective of the cellular immune responses against HAV, HBV, and HCV is included. Recent data pointing at the host (genetic), viral (genotype), and environmental factors that may account for the differential immune response in the admixed Mexican population are underlined. At the end of the chapter, the immune cells, cytokines, and metabolites with immunomodulatory functions related to liver injury are explained. We focus on discoveries that hold promise for identifying immunologic features in the resolution of viral hepatitis. © 2017 Elsevier Inc. All rights reserved.
Filiaciones:
Fierro N.A.:
Civil Hospital of Guadalajara, Fray Antonio Alcalde, Guadalajara, Mexico
University of Guadalajara, Guadalajara, Mexico
Gonzalez-Aldaco K.:
Civil Hospital of Guadalajara, Fray Antonio Alcalde, Guadalajara, Mexico
University of Guadalajara, Guadalajara, Mexico
Roman S.:
Civil Hospital of Guadalajara, Fray Antonio Alcalde, Guadalajara, Mexico
University of Guadalajara, Guadalajara, Mexico
Panduro A.:
Civil Hospital of Guadalajara, Fray Antonio Alcalde, Guadalajara, Mexico
University of Guadalajara, Guadalajara, Mexico
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