Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
Por:
Collier, Dami A., Ferreira, Isabella A. T. M., Kotagiri, Prasanti, Datir, Rawlings P., Lim, Eleanor Y., Touizer, Emma, Meng, Bo, Abdullahi, Adam, Elmer, Anne, Kingston, Nathalie, Graves, Barbara, Le Gresley, Emma, Caputo, Daniela, Bergamaschi, Laura, Smith, Kenneth G. C., Bradley, John R., Ceron-Gutierrez, Lourdes, Cortes-Acevedo, Paulina, Barcenas-Morales, Gabriela, Linterman, Michelle A., McCoy, Laura E., Davis, Chris, Thomson, Emma, Lyons, Paul A., McKinney, Eoin, Doffinger, Rainer, Wills, Mark, Gupta, Ravindra K., CITIID-NIHR BioResource COVID-19
Publicada:
19 ago 2021
Ahead of Print:
1 jun 2021
Categoría:
Multidisciplinary
Resumen:
Although two-dose mRNA vaccination provides excellent protection against
SARS-CoV-2, there is little information about vaccine efficacy against
variants of concern (VOC) in individuals above eighty years of age(1).
Here we analysed immune responses following vaccination with the
BNT162b2 mRNA vaccine(2) in elderly participants and younger healthcare
workers. Serum neutralization and levels of binding IgG or IgA after the
first vaccine dose were lower in older individuals, with a marked drop
in participants over eighty years old. Sera from participants above
eighty showed lower neutralization potency against the B.1.1.7 (Alpha),
B.1.351 (Beta) and P.1. (Gamma) VOC than against the wild-type virus and
were more likely to lack any neutralization against VOC following the
first dose. However, following the second dose, neutralization against
VOC was detectable regardless of age. The frequency of SARS-CoV-2
spike-specific memory B cells was higher in elderly responders (whose
serum showed neutralization activity) than in non-responders after the
first dose. Elderly participants showed a clear reduction in somatic
hypermutation of class-switched cells. The production of
interferon-gamma and interleukin-2 by SARS-CoV-2 spike-specific T cells
was lower in older participants, and both cytokines were secreted
primarily by CD4 T cells. We conclude that the elderly are a high-risk
population and that specific measures to boost vaccine responses in this
population are warranted, particularly where variants of concern are
circulating.
Filiaciones:
Kotagiri, Prasanti:
McKinney, E
Touizer, Emma:
McKinney, E
Meng, Bo:
McKinney, E
Abdullahi, Adam:
McKinney, E
Elmer, Anne:
McKinney, E
Kingston, Nathalie:
McKinney, E
Graves, Barbara:
McKinney, E
Le Gresley, Emma:
McKinney, E
Caputo, Daniela:
McKinney, E
Bergamaschi, Laura:
McKinney, E
Ceron-Gutierrez, Lourdes:
McKinney, E
Cortes-Acevedo, Paulina:
McKinney, E
Barcenas-Morales, Gabriela:
McKinney, E
Davis, Chris:
McKinney, E
Thomson, Emma:
McKinney, E
McKinney, Eoin:
McKinney, E
Doffinger, Rainer:
McKinney, E
Wills, Mark:
McKinney, E
CITIID-NIHR BioResource COVID-19:
McKinney, E
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