Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study
Por:
Gleichgerrcht E., Munsell B.C., Alhusaini S., Alvim M.K.M., Bargalló N., Bender B., Bernasconi A., Bernasconi N., Bernhardt B., Blackmon K., Caligiuri M.E., Cendes F., Concha L., Desmond P.M., Devinsky O., Doherty C.P., Domin M., Duncan J.S., Focke N.K., Gambardella A., Gong B., Guerrini R., Hatton S.N., Kälviäinen R., Keller S.S., Kochunov P., Kotikalapudi R., Kreilkamp B.A.K., Labate A., Langner S., Larivière S., Lenge M., Lui E., Martin P., Mascalchi M., Meletti S., O'Brien T.J., Pardoe H.R., Pariente J.C., Xian Rao J., Richardson M.P., Rodríguez-Cruces R., Rüber T., Sinclair B., Soltanian-Zadeh H., Stein D.J., Striano P., Taylor P.N., Thomas R.H., Elisabetta Vaudano A., Vivash L., von Podewills F., Vos S.B., Weber B., Yao Y., Lin Yasuda C., Zhang J., Thompson P.M., Sisodiya S.M., McDonald C.R., Bonilha L., Altmann A., Depondt C., Galovic M., Thomopoulos S.I., Wiest R., ENIGMA-Epilepsy Working Group
Publicada:
1 ene 2021
Resumen:
Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or medical imaging findings. Brain magnetic resonance imaging (MRI) is a key assessment tool for patients with temporal lobe epilepsy (TLE). The role of machine learning and artificial intelligence to increase detection of brain abnormalities in TLE remains inconclusive. We used support vector machine (SV) and deep learning (DL) models based on region of interest (ROI-based) structural (n = 336) and diffusion (n = 863) brain MRI data from patients with TLE with (“lesional”) and without (“non-lesional”) radiographic features suggestive of underlying hippocampal sclerosis from the multinational (multi-center) ENIGMA-Epilepsy consortium. Our data showed that models to identify TLE performed better or similar (68–75%) compared to models to lateralize the side of TLE (56–73%, except structural-based) based on diffusion data with the opposite pattern seen for structural data (67–75% to diagnose vs. 83% to lateralize). In other aspects, structural and diffusion-based models showed similar classification accuracies. Our classification models for patients with hippocampal sclerosis were more accurate (68–76%) than models that stratified non-lesional patients (53–62%). Overall, SV and DL models performed similarly with several instances in which SV mildly outperformed DL. We discuss the relative performance of these models with ROI-level data and the implications for future applications of machine learning and artificial intelligence in epilepsy care. © 2021 The Authors
Filiaciones:
Gleichgerrcht E.:
Department of Neurology, Medical University of South Carolina, Charleston, SC, United States
Munsell B.C.:
Department of Psychiatry, University of North Carolina at Chapel HillNC, United States
Department of Computer Science, University of North Carolina at Chapel HillNC, United States
Alhusaini S.:
Neurology Department, Yale University School of Medicine, New Haven, CT, United States
Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
Alvim M.K.M.:
Department of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, SP, Brazil
Bargalló N.:
Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
Department of Radiology of Center of Image Diagnosis (CDIC), Hospital Clinic de Barcelona, Barcelona, Spain
Bender B.:
Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany
Bernasconi A.:
Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
Bernasconi N.:
Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
Bernhardt B.:
McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
Blackmon K.:
Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, United States
Caligiuri M.E.:
Neuroscience Research Center, Department of Medical and Surgical Sciences, University “Magna Græcia“ of Catanzaro, Catanzaro, Italy
Cendes F.:
Department of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, SP, Brazil
Concha L.:
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico
Desmond P.M.:
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia
Devinsky O.:
Department of Neurology, Langone School of Medicine, New York University, New York, NY, United States
Doherty C.P.:
Trinity College Dublin, School of Medicine, Dublin, Ireland
FutureNeuro SFI Research Centre for Rare and Chronic Neurological Diseases, Dublin, Ireland
Domin M.:
Functional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
Duncan J.S.:
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK, United Kingdom
UCL Queen Square Institute of Neurology, London, UK, United Kingdom
Focke N.K.:
University Medicine Göttingen, Clinical Neurophysiology, Göttingen, Germany
Gambardella A.:
Neuroscience Research Center, Department of Medical and Surgical Sciences, University “Magna Græcia“ of Catanzaro, Catanzaro, Italy
Institute of Neurology, University “Magna Græcia“ of Catanzaro, Catanzaro, Italy
Gong B.:
Department of Radiology, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada
Guerrini R.:
Neuroscience Department, University of Florence, Florence, Italy
Hatton S.N.:
Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, United States
Kälviäinen R.:
Kuopio University Hospital, Member of EpiCARE ERN, Kuopio, Finland
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
Keller S.S.:
Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom
The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom
Kochunov P.:
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States
Kotikalapudi R.:
Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany
Department of Clinical Neurophysiology, University Hospital Göttingen, Goettingen, Germany
Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Tübingen, Germany
Kreilkamp B.A.K.:
University Medicine Göttingen, Clinical Neurophysiology, Göttingen, Germany
Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom
Labate A.:
Neuroscience Research Center, Department of Medical and Surgical Sciences, University “Magna Græcia“ of Catanzaro, Catanzaro, Italy
Institute of Neurology, University “Magna Græcia“ of Catanzaro, Catanzaro, Italy
Langner S.:
Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
Institute for Diagnostic and Interventional Radiology, Pediatric and Neuroradiology, University Medical Centre Rostock, Rostock, Germany
Larivière S.:
McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
Lenge M.:
Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy
Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy
Lui E.:
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia
Martin P.:
Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Tübingen, Germany
Mascalchi M.:
‘Mario Serio’ Department of Clinical and Experimental Medica Sciences, University of Florence, Florence, Italy
Meletti S.:
Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Neurology Unit, OCB Hospital, AOU Modena, Modena, Italy
O'Brien T.J.:
Department of Neuroscience, Monash University, Melbourne, VIC, Australia
The Department of Medicine (The Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia
Department of Neurology, Alfred Health, Melbourne, VIC, Australia
Pardoe H.R.:
Department of Neurology, Langone School of Medicine, New York University, New York, NY, United States
Pariente J.C.:
Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
Xian Rao J.:
Department of Psychiatry, University of California San Diego, La Jolla, CA, United States
Richardson M.P.:
Division of Neuroscience, King's College London, London, UK, United Kingdom
Rodríguez-Cruces R.:
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico
Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada
Rüber T.:
Department of Epileptology, University Hospital Bonn, Bonn, Germany
Sinclair B.:
Department of Neuroscience, Monash University, Melbourne, VIC, Australia
The Department of Medicine (The Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia
Department of Neurology, Alfred Health, Melbourne, VIC, Australia
Soltanian-Zadeh H.:
Radiology and Research Administration, Henry Ford Health System, Detroit, MI, United States
School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran
Stein D.J.:
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa
Striano P.:
IRCCS Istituto ‘G. Gaslini’, Genova, Italy
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
Taylor P.N.:
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
School of Computing, Newcastle University, Newcastle Upon Tyne, United Kingdom
Thomas R.H.:
Institute of Translational and Clinical Research, Newcastle University, Newcastle Upon Tyne, United Kingdom
Elisabetta Vaudano A.:
Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Neurology Unit, OCB Hospital, AOU Modena, Modena, Italy
Vivash L.:
Department of Neuroscience, Monash University, Melbourne, VIC, Australia
The Department of Medicine (The Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia
Department of Neurology, Alfred Health, Melbourne, VIC, Australia
von Podewills F.:
Department of Neurology, Epilepsy Center, University Medicine Greifswald, Greifswald, Germany
Vos S.B.:
Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK, United Kingdom
Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK, United Kingdom
Weber B.:
Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany
Yao Y.:
Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany
Lin Yasuda C.:
Department of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, SP, Brazil
Zhang J.:
Cognitive Science Department, School of Informatics, Xiamen University, Xiamen, China
Thompson P.M.:
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del ReyCA, United States
Sisodiya S.M.:
UCL Queen Square Institute of Neurology, London, UK, United Kingdom
Chalfont Centre for EpilepsyBucks, UK
McDonald C.R.:
Department of Psychiatry, University of California San Diego, La Jolla, CA, United States
Bonilha L.:
Department of Neurology, Medical University of South Carolina, Charleston, SC, United States
Altmann A.:
Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK, United Kingdom
Depondt C.:
Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Galovic M.:
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK, United Kingdom
UCL Queen Square Institute of Neurology, London, UK, United Kingdom
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
Thomopoulos S.I.:
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del ReyCA, United States
Wiest R.:
Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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