Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution
Por:
Romero, Yair, Aquino-Galvez, Arnoldo
Publicada:
1 ago 2021
Resumen:
Adaptive responses to hypoxia are involved in the progression of lung
cancer and pulmonary fibrosis. However, it has not been pointed out that
hypoxia may be the link between these diseases. As tumors or scars
expand, a lack of oxygen results in the activation of the hypoxia
response, promoting cell survival even during chronic conditions. The
role of hypoxia-inducible factors (HIFs) as master regulators of this
adaptation is crucial in both lung cancer and idiopathic pulmonary
fibrosis, which have shown the active transcriptional signature of this
pathway. Emerging evidence suggests that interconnected feedback loops
such as metabolic changes, fibroblast differentiation or extracellular
matrix remodeling contribute to HIF overactivation, making it an
irreversible phenomenon. This review will focus on the role of HIF
signaling and its possible overlapping in order to identify new
opportunities in therapy and regeneration.
Filiaciones:
Romero, Yair:
Romero, Y (Corresponding Author), Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico. Aquino-Galvez, A (Corresponding Author), Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City 14080, DF, Mexico. Romero, Yair, Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico. Aquino-Galvez, Arnoldo, Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City 14080, DF, Mexico
Aquino-Galvez, Arnoldo:
Romero, Y (Corresponding Author), Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico. Aquino-Galvez, A (Corresponding Author), Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City 14080, DF, Mexico. Romero, Yair, Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico. Aquino-Galvez, Arnoldo, Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City 14080, DF, Mexico
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