SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants
Por:
Martinez-Flores, Daniel, Zepeda-Cervantes, Jesus, Cruz-Resendiz, Adolfo, Aguirre-Sampieri, Sergio, SAMPIERI, ALICIA, Vaca, Luis
Publicada:
12 jul 2021
Resumen:
Coronavirus 19 Disease (COVID-19) originating in the province of Wuhan,
China in 2019, is caused by the severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2), whose infection in humans causes mild
or severe clinical manifestations that mainly affect the respiratory
system. So far, the COVID-19 has caused more than 2 million deaths
worldwide. SARS-CoV-2 contains the Spike (S) glycoprotein on its
surface, which is the main target for current vaccine development
because antibodies directed against this protein can neutralize the
infection. Companies and academic institutions have developed vaccines
based on the S glycoprotein, as well as its antigenic domains and
epitopes, which have been proven effective in generating neutralizing
antibodies. However, the emergence of new SARS-CoV-2 variants could
affect the effectiveness of vaccines. Here, we review the different
types of vaccines designed and developed against SARS-CoV-2, placing
emphasis on whether they are based on the complete S glycoprotein, its
antigenic domains such as the receptor-binding domain (RBD) or short
epitopes within the S glycoprotein. We also review and discuss the
possible effectiveness of these vaccines against emerging SARS-CoV-2
variants.
Filiaciones:
Martinez-Flores, Daniel:
Vaca, L (Corresponding Author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City, DF, Mexico. Martinez-Flores, Daniel
Zepeda-Cervantes, Jesus:
Vaca, L (Corresponding Author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City, DF, Mexico. Martinez-Flores, Daniel
Cruz-Resendiz, Adolfo:
Vaca, L (Corresponding Author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City, DF, Mexico. Martinez-Flores, Daniel
Aguirre-Sampieri, Sergio:
Vaca, L (Corresponding Author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City, DF, Mexico. Martinez-Flores, Daniel
SAMPIERI, ALICIA:
Vaca, L (Corresponding Author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City, DF, Mexico. Martinez-Flores, Daniel
Vaca, Luis:
Vaca, L (Corresponding Author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City, DF, Mexico. Martinez-Flores, Daniel
Open Access
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