Physicochemical and Biopharmaceutical Evaluation of Casiopeina III-Ea, a New Compound with Antineoplastic Activity
Por:
Vara-Gama, Nancy, Rubio-Carrasco, Kenneth, Espinoza-Guillen, Adrian, Ruiz-Azuara, Lena, Fuentes-Noriega, Ines
Publicada:
1 ene 2021
Categoría:
Chemistry (miscellaneous)
Resumen:
In the present work, the physicochemical (pka, intrinsic solubility, Log
D distribution coefficient) and biopharmaceutical characterization (IC50
studies in MDCK cells) of Casiopeina III-Ea, a Cu (II) mixed chelate
compound, was carried out. These parameters will tell us about the
behaviour of Casiopeina III-Ea, as a new antineoplastic agent, in
physiological media. This basic research of the Faculty of Chemistry of
the UNAM, is directed towards the maturation of a technology, which
consists of the pharmaceutical development of an antineoplastic copper
coordination compound Casiopeina III-Ea.
Filiaciones:
Vara-Gama, Nancy:
Univ Nacl Autonoma Mexico, Dept Inorgan & Nucl Chem, Bldg B, Mexico City 04510, DF, Mexico
Rubio-Carrasco, Kenneth:
Univ Nacl Autonoma Mexico, Dept Pharm, Fac Chem, Bldg E, Mexico City 04510, DF, Mexico
Espinoza-Guillen, Adrian:
Univ Nacl Autonoma Mexico, Dept Inorgan & Nucl Chem, Bldg B, Mexico City 04510, DF, Mexico
Ruiz-Azuara, Lena:
Univ Nacl Autonoma Mexico, Dept Inorgan & Nucl Chem, Bldg B, Mexico City 04510, DF, Mexico
Fuentes-Noriega, Ines:
Univ Nacl Autonoma Mexico, Dept Pharm, Fac Chem, Bldg E, Mexico City 04510, DF, Mexico
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