Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats
Por:
Martiñón-Gutiérrez G., Luna-Castro, Maria, Hernandez-Munoz, Rolando
Publicada:
3 jun 2021
Categoría:
Multidisciplinary
Resumen:
The exposure to extremely low-frequency electromagnetic fields (EMFs)
could adversely affect the endocrine system and cellular proliferative
response. Nonetheless, the use of 60-Hz EMFs in the form of
magneto-therapy exerts beneficial actions on human health but can also
induce hyperglycaemia. Therefore, the present study was aimed to search
for metabolic responses of fed or fasted male rats to a single EMF
exposure. We performed a 15 min-single exposure to 60-Hz (3.8 mT,
intensity) EMF, and determined serum levels of glucose, lipids, and
indicators of cellular redox state and energy parameters. A single
exposure to a 60-Hz EMF induced hyperglycaemia in both animal groups,
and an attenuated second serum insulin peak. The 60-Hz EMF also
decreased free fatty acids and lactate serum levels, oppositely
increasing pyruvate and acetoacetate levels. Significant increases in
blood glucose level and rat's glucose metabolism were related to a more
oxidized cellular redox state and variations in insulin and glucagon
secretion. The 60-Hz EMF's effects were not modified in animals
previously subjected to chronic EMFs exposure (14 days). In conclusion,
increased serum glucose levels and glucose metabolism induced by a
single 60-Hz EMF exposure were closely related to the cellular redox
state and the insulin/glucagon ratio.
Filiaciones:
Martiñón-Gutiérrez G.:
Department of Cell Biology and Development, Institute of Cellular Physiology, Universidad Nacional Autónoma de México (UNAM), Ave. Universidad # 3000, Apdo. Postal 70-243, Coyoacán, Mexico City, 04510, Mexico
Luna-Castro, Maria:
Department of Cell Biology and Development, Institute of Cellular Physiology, Universidad Nacional Autónoma de México (UNAM), Ave. Universidad # 3000, Apdo. Postal 70-243, Coyoacán, Mexico City, 04510, Mexico
Hernandez-Munoz, Rolando:
Department of Cell Biology and Development, Institute of Cellular Physiology, Universidad Nacional Autónoma de México (UNAM), Ave. Universidad # 3000, Apdo. Postal 70-243, Coyoacán, Mexico City, 04510, Mexico
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