From RNA to DNA: Insights about the transition of informational molecule in the biological systems based on the structural proximity between the polymerases
Por:
Pereira dos Santos Junior A., Jose, Marco V., Torres de Farias S.
Publicada:
1 ago 2021
Resumen:
Structural relations in an evolutionary context of polymerases is
crucial to gain insights into the transition from an RNA world to a
Ribonucleoprotein world. Herein, we present a structural proximity tree
for the polymerases, from which we observe that the enzymes that have
RNA as substrate are more homogeneous than the group with DNA as
substrate. The homogeneity observed in enzymes with RNA as a substrate,
may be because they performed all steps in information processing. In
this sense, the emergence of the DNA molecule posed new challenges to
the biological systems, where several parts of the informational flow
were individualized by the emergence of enzymes for each step. From the
data presented, we propose a polymerase diversification model, in which
we have RNA-dependent RNA polymerases as an ancestor and all other
polymerases diverged directly from this group by a radiation process.
Filiaciones:
Pereira dos Santos Junior A.:
Departamento de Biologia Molecular, Universidade Federal da Paraíba, João Pessoa, 58051-900, Brazil
Jose, Marco V.:
Theoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510, Mexico
Torres de Farias S.:
Departamento de Biologia Molecular, Universidade Federal da Paraíba, João Pessoa, 58051-900, Brazil
Network of Researchers on the Chemical Evolution of Life (NoRCEL), Leeds, LS7 3RB, United Kingdom
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