Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps
Por:
Bautista-Becerril, Brandon, Campi-Caballero, Rebeca, Sevilla-Fuentes, Samuel, Hernandez-Regino, Laura M., Hanono, Alejandro, Flores-Bustamante, Al, Gonzalez-Flores, Julieta, Garcia-Avila, Carlos A., Aquino-Galvez, Arnoldo, Castillejos-Lopez, Manuel, Juarez-Cisneros, Armida, Camarena, Angel
Publicada:
1 may 2021
Resumen:
SARS-CoV-2 is a member of the family of coronaviruses associated with
severe outbreaks of respiratory diseases in recent decades and is the
causative agent of the COVID-19 pandemic. The recognition by and
activation of the innate immune response recruits neutrophils, which,
through their different mechanisms of action, form extracellular
neutrophil traps, playing a role in infection control and trapping
viral, bacterial, and fungal etiological agents. However, in patients
with COVID-19, activation at the vascular level, combined with other
cells and inflammatory mediators, leads to thrombotic events and
disseminated intravascular coagulation, thus leading to a series of
clinical manifestations in cerebrovascular, cardiac, pulmonary, and
kidney disease while promoting severe disease and mortality. Previous
studies of hospitalized patients with COVID-19 have shown that elevated
levels of markers specific for NETs, such as free DNA, MPO, and H3Cit,
are strongly associated with the total neutrophil count; with acute
phase reactants that include CRP, D-dimer, lactate dehydrogenase, and
interleukin secretion; and with an increased risk of severe COVID-19.
This study analyzed the interactions between NETs and the activation
pathways involved in immunothrombotic processes in patients with
COVID-19.
Filiaciones:
Bautista-Becerril, Brandon:
Inst Nacl Enfermedades Resp Ismael Cosio, Lab HLA, Mexico City 14080, DF, Mexico
Univ Nacl Autonoma Mexico, FES Iztacala, Programa MEDICI, Carrera Med Cirujano, Mexico City 54090, DF, Mexico
Campi-Caballero, Rebeca:
Univ Nacl Autonoma Mexico, FES Iztacala, Programa MEDICI, Carrera Med Cirujano, Mexico City 54090, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Lab Neuropsicofarmacol, Mexico City 04510, DF, Mexico
Sevilla-Fuentes, Samuel:
Hosp Gen Mexico Eduardo Liceaga, Dept Infectol, Mexico City 06720, DF, Mexico
Hernandez-Regino, Laura M.:
Inst Politecn Nacl, Programa Posgrad, Escuela Nacl Ciencias Biol, Mexico City 11340, DF, Mexico
Hanono, Alejandro:
Univ Anahuac Mexico Norte, Fac Ciencias Salud, Mexico City 52786, DF, Mexico
Flores-Bustamante, Al:
Inst Nacl Pediat, Lab Farmacol, Mexico City 04530, DF, Mexico
Gonzalez-Flores, Julieta:
Univ Nacl Autonoma Mexico, FES Iztacala, Programa MEDICI, Carrera Med Cirujano, Mexico City 54090, DF, Mexico
Garcia-Avila, Carlos A.:
Inst Politecn Nacl, Programa Posgrad, Escuela Nacl Ciencias Biol, Mexico City 11340, DF, Mexico
Aquino-Galvez, Arnoldo:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Fibrosis Pulmonar, Lab Biol Mol, Mexico City 14080, DF, Mexico
Castillejos-Lopez, Manuel:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Epidemiol Hosp & Infectol, Mexico City 14080, DF, Mexico
Juarez-Cisneros, Armida:
Inst Nacl Enfermedades Resp Ismael Cosio, Lab HLA, Mexico City 14080, DF, Mexico
Camarena, Angel:
Inst Nacl Enfermedades Resp Ismael Cosio, Lab HLA, Mexico City 14080, DF, Mexico
Gold, Green Published, Green
|