Increased risk of depression and impairment in quality of life in patients with lamellar ichthyosis
Por:
Cortes, Hernan, Rojas-Marquez, Martin, Reyes-Hernandez, Octavio D., Morales-Morfin, Juan C., Guapillo-Vargas M.R.B., Varela-Cardoso, Miguel, Magaña J.J., Leyva-Gomez, Gerardo, Gonzalez-del Carmen, Manuel
Publicada:
1 ene 2021
Resumen:
Lamellar ichthyosis (LI) is a genetic skin disorder characterized by
dark brown scales, palmoplantar hyperkeratosis, pain, and itching. LI
severity could have implications in psychological aspects, causing
depression and impairment in the quality of life (QoL) of patients. In
this study, we used the Congenital Ichthyosis Severity Index, the
Depression Beck Inventory-II (DBI-II), and the Dermatologic Life Quality
Index (DLQI) to assess severity, level of depression, and impairment in
QoL in a group of patients with LI. We observed that the majority of the
patients presented a high severity level concerning the presence of
scales (57.7%), while for erythema and alopecia, the severity was less
80% of the analyzed patients presented depression, while only 20.8% of
individuals of the control group presented it (P < .001, OR = 15.2).
While for QoL, only 4.3% of the patients did not exhibit any
impairment. Finally, the increase in the score obtained in DBI-II was
correlated with the DLQI score (rs = 0.663, P = .0014). Our results
suggest that patients with LI have an increased risk of suffering
depression and impairment in their QoL; thus, the management of their
disease should be performed from a multidisciplinary perspective to
improve the global aspects of their lives.
Filiaciones:
Cortes, Hernan:
Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de Mexico, Mexico
Rojas-Marquez, Martin:
Hospital Psiquiátrico Infantil Dr. Juan N. Navarro, Secretaría de Salud, Ciudad de México, Mexico
Reyes-Hernandez, Octavio D.:
Laboratorio de Biología Molecular del Cáncer, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Morales-Morfin, Juan C.:
Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de Mexico, Mexico
Guapillo-Vargas M.R.B.:
Facultad de Ciencias Químicas, Universidad Veracruzana, Veracruz, Mexico
Varela-Cardoso, Miguel:
Facultad de Medicina, Universidad Veracruzana, Veracruz, Mexico
Magaña J.J.:
Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de Mexico, Mexico
Escuela de Ingeniería y Ciencias, Departamento de Bioingeniería, Tecnológico de Monterrey Campus Ciudad de México, Ciudad de México, Mexico
Leyva-Gomez, Gerardo:
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Gonzalez-del Carmen, Manuel:
Facultad de Medicina, Universidad Veracruzana, Veracruz, Mexico
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