Mechanisms of infection by SARS-CoV-2, inflammation and potential links with the microbiome
Por:
Garciá M.M.A., Mancilla-Galindo J., Paredes-Paredes M., Tiburcio A.Z., Ávila-Vanzzini N.
Publicada:
1 ene 2021
Categoría:
Virology
Resumen:
The pandemic SARS coronavirus 2 utilizes efficient mechanisms to establish infection and evade the immune system. Established infection leads to severe inflammation in susceptible patients, the main hallmark of progression to severe coronavirus disease (COVID-19). Knowledge of the mechanisms of disease has expanded rapidly. As inflammation emerges as the central pathophysiological feature in COVID-19, elucidating how the immune system, lungs and gut communicate and interact with microbial components of the ecological niches that conform the human microbiome will shed light on how inflammation and disease progression are promoted. Studying the microbiome in COVID-19 could allow scientists to identify novel approaches to prevent severe inflammation by targeting components of the human microbiome. Innovation in the aforementioned is needed to combat this pandemic. © 2021 Future Medicine Ltd.
Filiaciones:
Garciá M.M.A.:
División de Investigación, Facultad de Medicina, Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiologiá Ignacio Chávez, Juan Badiano No. 1, Ciudad de México, 14080, Mexico
Mancilla-Galindo J.:
División de Investigación, Facultad de Medicina, Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiologiá Ignacio Chávez, Juan Badiano No. 1, Ciudad de México, 14080, Mexico
Paredes-Paredes M.:
División de Investigación, Facultad de Medicina, Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiologiá Ignacio Chávez, Juan Badiano No. 1, Ciudad de México, 14080, Mexico
Tiburcio A.Z.:
Departamento de Gastroenterologiá, Unidad de Trasplante de Microbiota Intestinal, Especialidades Médicas Nápoles, Oficina 12, Benito Juárez, Ciudad de México, 03810, Mexico
Ávila-Vanzzini N.:
Departamento de Consulta Externa, Instituto Nacional de Cardiologiá Ignacio Chávez, Juan Badiano No. 1, Ciudad de México, 14080, Mexico
|