Gray and white matter morphology in substance use disorders: a neuroimaging systematic review and meta-analysis
Por:
Pando-Naude, Victor, Toxto, Sebastian, Fernandez-Lozano, Sofia, Parsons, Christine E., ALCAUTER, SARAEL, Garza-Villarreal, Eduardo A.
Publicada:
11 ene 2021
Resumen:
Substance use disorders (SUDs) are characterized by a compulsion to seek
and consume one or more substances of abuse, with a perceived loss of
control and a negative emotional state. Prolonged substance use seems to
be associated with morphological changes of multiple neural circuits, in
particular the frontal-striatal and limbic pathways. Such
neuroadaptations are evident across several substance disorders, but may
vary depending on the type of substance, consumption severity and/or
other unknown factors. We therefore identified studies investigating the
effects of SUDs using volumetric whole-brain voxel-based morphometry
(VBM) in gray (GM) and white matter (WM). We performed a systematic
review and meta-analysis of VBM studies using the anatomic likelihood
estimation (ALE) method implemented in GingerALE (PROSPERO
pre-registration CRD42017071222). Sixty studies met inclusion criteria
and were included in the final quantitative meta-analysis, with a total
of 614 foci, 94 experiments and 4938 participants. We found convergence
and divergence in brain regions and volume effects (higher vs. lower
volume) in GM and WM depending on the severity of the consumption
pattern and type of substance used. Convergent pathology was evident
across substances in GM of the insula, anterior cingulate cortex,
putamen, and thalamus, and in WM of the thalamic radiation and internal
capsule bundle. Divergent pathology between occasional use (cortical
pathology) and addiction (cortical-subcortical pathology) provides
evidence of a possible top-down neuroadaptation. Our findings indicate
particular brain morphometry alterations in SUDs, which may inform our
understanding of disease progression and ultimately therapeutic
approaches.
Filiaciones:
Pando-Naude, Victor:
Univ Aarhus, Ctr Mus Brain, Dept Clin Med, Aarhus, Denmark
Toxto, Sebastian:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Campus Juriquilla, Queretaro, Mexico
Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico
Fernandez-Lozano, Sofia:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Campus Juriquilla, Queretaro, Mexico
Univ Nacl Autonoma Mexico, Fac Psicol, Mexico City, DF, Mexico
Parsons, Christine E.:
Univ Aarhus, Dept Clin Med, Interacting Minds Ctr, Aarhus, Denmark
ALCAUTER, SARAEL:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Campus Juriquilla, Queretaro, Mexico
Garza-Villarreal, Eduardo A.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Campus Juriquilla, Queretaro, Mexico
Univ Aarhus, Dept Clin Med, Ctr Functionally Integrat Neurosci, Aarhus, Denmark
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