Towards translation of surface-enhanced Raman spectroscopy (SERS) to clinical practice: Progress and trends
Por:
Panikar, Sandeep Surendra, Cialla-May, Dana, De la Rosa, Elder, Salas, Pedro, Popp, Juergen
Publicada:
1 ene 2021
Resumen:
Surface-enhanced Raman spectroscopy (SERS) has demonstrated potential for various biomedical applications. However, when these sensors/substrates are exposed for analysis of complex biological fluids, their sensitivity is gradually decreased due to fouling of proteins on the plasmonic substrates, leading to hotspot blockade. To overcome this limitation, immense efforts have been devoted in recent times to develop stealth SERS substrates to maintain sensing capabilities in clinical samples. Two important methods have been proposed for developing stealth SERS with the use of zwitterionic molecules and nanoshearing force. These stealth modification strategies help reduce the background noise and enhance the sensing capability with their antifouling features for point-of-care-testing (POCT). Additionally, we have highlighted some of the recent SERS developments that demonstrate reliable stealth and sensitivity when employed for diagnosis or personalized treatment. Herein, we concisely review and discuss the future of SERS for investigations in complex clinical samples. © 2020 Elsevier B.V.
Filiaciones:
Panikar, Sandeep Surendra:
Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Apartado Postal 1-1010, Querétaro, Qro 76000, Mexico
Cialla-May, Dana:
Leibniz Institute of Photonic Technology, Member of the Leibniz Research Alliance, Leibniz Health Technologies, Albert-Einstein-Str. 9, Jena, 07745, Germany
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Helmholtzweg 4, Jena, 07743, Germany
De la Rosa, Elder:
Universidad De La Salle Bajio, Campus Campestre, León, Guanajuato 37150, Mexico
Salas, Pedro:
Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Apartado Postal 1-1010, Querétaro, Qro 76000, Mexico
Popp, Juergen:
Leibniz Institute of Photonic Technology, Member of the Leibniz Research Alliance, Leibniz Health Technologies, Albert-Einstein-Str. 9, Jena, 07745, Germany
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Helmholtzweg 4, Jena, 07743, Germany
Univ Nacl Autonoma Mexico, Ctr Fis Aplicada & Tecnol Avanzada, Apartado Postal 1-1010, Queretaro 76000, Qro, Mexico
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