Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals
Por:
Martinez-Pacheco, Monica, Tenorio, Mariela, Almonte, Laura, Fajardo, Vicente, Godinez, Alan, Fernandez, Diego, Cornejo-Paramo, Paola, Diaz-Barba, Karina, Halbert, Jean, Liechti, Angelica, Szekely, Tamas, Urrutia, Araxi O., Cortez, Diego
Publicada:
1 nov 2020
Resumen:
Placental mammals present 180 million-year-old Y chromosomes that have
retained a handful of dosage-sensitive genes. However, the expression
evolution of Y-linked genes across placental groups has remained largely
unexplored. Here, we expanded the number of Y gametolog sequences by
analyzing ten additional species from previously unexplored groups. We
detected seven remarkably conserved genes across 25 placental species
with known Y repertoires. We then used RNA-seq data from 17 placental
mammals to unveil the expression evolution of XY gametologs. We found
that Y gametologs followed, on average, a 3-fold expression loss and
that X gametologs also experienced some expression reduction,
particularly in primates. Y gametologs gained testis specificity through
an accelerated expression decay in somatic tissues. Moreover, despite
the substantial expression decay of Y genes, the combined expression of
XY gametologs in males is higher than that of both X gametologs in
females. Finally, our work describes several features of the Y
chromosome in the last common mammalian ancestor.
Filiaciones:
Martinez-Pacheco, Monica:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
Tenorio, Mariela:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
Almonte, Laura:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
Fajardo, Vicente:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
Godinez, Alan:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
Fernandez, Diego:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
Cornejo-Paramo, Paola:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
Diaz-Barba, Karina:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
Halbert, Jean:
Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland
Liechti, Angelica:
Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland
Szekely, Tamas:
Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England
Urrutia, Araxi O.:
Univ Nacl Autonoma Mexico, Ecol Inst, Mexico City, DF, Mexico
Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England
Cortez, Diego:
UNAM, Ctr Genome Sci, Cuernavaca, Morelos, Mexico
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