Hippocampal Unicellular Recordings and Hippocampal-dependent Innate Behaviors in an Adolescent Mouse Model of Alzheimer's disease
Por:
Mondragon-Rodriguez, Siddhartha, Ordaz, Benito, Orta-Salazar, Erika, Diaz-Cintra, Sofia, Pena-Ortega, Fernando, Perry, George
Publicada:
20 feb 2020
Resumen:
Transgenic mice have been used to make valuable contributions to the
field of neuroscience and model neurological diseases. The simultaneous
functional analysis of hippocampal cell activity combined with
hippocampal dependent innate task evaluations provides a reliable
experimental approach to detect fine changes during early phases of
neurodegeneration. To this aim, we used a merge of patch-clamp with two
hippocampal innate behavior tasks. With this experimental approach,
whole-cell recordings of CA1 pyramidal cells, combined with
hippocampal-dependent innate behaviors, have been crucial for evaluating
the early mechanism of neurodegeneration and its consequences. Here, we
present our protocol for ex vivo whole-cell recordings of CA1 pyramidal
cells and hippocampal dependent innate behaviors in an adolescent (p30)
mice.
Filiaciones:
Mondragon-Rodriguez, Siddhartha:
Natl Council Sci & Technol CONACYT, Mexico City, DF, Mexico
Natl Autonomous Univ Mexico UNAM, Inst Neurobiol, Dev Neurobiol & Neurophysiol, Queretaro, Mexico
Ordaz, Benito:
Natl Autonomous Univ Mexico UNAM, Inst Neurobiol, Dev Neurobiol & Neurophysiol, Queretaro, Mexico
Orta-Salazar, Erika:
Natl Autonomous Univ Mexico UNAM, Inst Neurobiol, Dev Neurobiol & Neurophysiol, Queretaro, Mexico
Diaz-Cintra, Sofia:
Natl Autonomous Univ Mexico UNAM, Inst Neurobiol, Dev Neurobiol & Neurophysiol, Queretaro, Mexico
Pena-Ortega, Fernando:
Natl Autonomous Univ Mexico UNAM, Inst Neurobiol, Dev Neurobiol & Neurophysiol, Queretaro, Mexico
Perry, George:
Univ Texas San Antonio UTSA, Coll Sci, Neurosci Inst, San Antonio, TX USA
Univ Texas San Antonio UTSA, Coll Sci, Dept Biol, San Antonio, TX USA
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