Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy
Por:
Gutiérrez-Vargas R., Villasis-Keever M.Á., Portilla-Robertson J., Ascencio-Montiel I.J., Zapata-Tarrés M.
Publicada:
1 ene 2020
Resumen:
Background: Oropharyngeal mucositis (OM) is one of the main side-effects of oncological therapy. There is no treatment to prevent its occurrence, but some zinc-based therapies have been proven to help in decreasing its in-tensity. The objective of this study was to determine the effect of zinc in OM in children with acute leukemia in the early stages of oncological treatment. Material and Methods: This quasi-experimental study evaluated OM in 2 groups (control group: conventional hospital management, and experimental group: administration of 50 mg of zinc gluconate daily plus conventional hospital management). OM severity was recorded at a two-month follow-up. Results: Forty-nine patients (26 in the control group and 23 in the experimental group) were included. The mean age of the patients was 11.1 ± 2.7 years; 65.3% had a diagnosis of pre-B acute lymphoblastic leukemia. The inci-dences of OM in the control group and the experimental group were 46.2% and 26.1%, respectively, but the differ-ence was not significant. Based on a negative binomial regression model, females had, on average, 1.5 more days with OM (p = 0.002), and patients assigned to the experimental group had, on average, 2 less days with OM than the control group (p = 0.001). The pain score was higher in the control group (p = 0.0009), as was the mean score on the WHO scale (p = 0.0012). Conclusions: Zinc facilitated a reduction in the severity and duration of OM; further studies focusing on children are needed to confirm the effects of this trace element. © Medicina Oral S. L.
Filiaciones:
Gutiérrez-Vargas R.:
Dentistry and Health Sciences, National Autonomous University of Mexico, Mexico
Villasis-Keever M.Á.:
Research Unit in Analysis and Synthesis of Evidence, High Specialty Medical, Hospital of Pediatrics. XXI Century National Medical Center, Mexican Social Security Institute, Mexico
Portilla-Robertson J.:
Coordination of Oral Pathology, Division of Graduate Studies, Faculty of Dentistry, National Autonomous University of Mexico, Mexico
Ascencio-Montiel I.J.:
Coordination of Epidemiological Surveillance, Mexican Social Security Institute, Mexico
Zapata-Tarrés M.:
Department of Medical Oncology, National Institute of Pediatrics, Health Secretary. Research Coordination, Fundación IMSS, A.C., Mexico
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