DETERMINATION OF 2-HYDROXYESTRONE/16 alpha-HYDROXYESTRONE RATIO IN URINE OF MEXICAN WOMEN AS A RISK INDICATOR FOR BREAST CANCER AND ITS RELATIONSHIP WITH OTHER RISK FACTORS
Por:
Godinez Martinez, Estela Ytelina, Santillan Ballesteros, Rene, Lemus Bravo, Ana Elena, Samano, Reyna, Tolentino Dolores, Maricruz, Rodriguez Ventura, Ana Lilia, Juarez Gonzalez, Ana Rosa
Publicada:
1 feb 2015
Resumen:
The urinary ratio 2-hydroxyoestrone/16 alpha-hydroxyoestrone (URME), has
been proposed in various populations on the world as a risk indicator
for breast cancer (BC), however in the Mexican population has never been
determined.
Objective: To determine URME Mexican women and establish its
relationship with risk factors for BC.
Material and Methods: Cross-sectional study of 142 premenopausal and 42
posmenopausal women. The URME was determined with the kit ESTRAMET (TM)
and was related to risk factors for BC. Correlations and linear
regressions were performed.
Results: The median URME was 0.90 (RIQ 0.64-1.18). The body mass index
(BMI) and early menarche contribute 5.4% of their variability (F=5.17;
p<0.000). IMC participated in 6.1% of the variability of
2-hydroxyoestrone in premenopausal (F=4.40; p<0.000) and 18.1% in
posmenopausal women (F=8.85; p<0.000).
Conclusion: The URME was approximate to 50% lower than reported for
other populations and inversely proportional to BMI.
Filiaciones:
Godinez Martinez, Estela Ytelina:
Inst Nacl Perinatol, Dept Nutr & Bioprogramac, Mexico City, DF, Mexico
Santillan Ballesteros, Rene:
Inst Nacl Perinatol, Dept Infectol & Inmunol, Mexico City, DF, Mexico
Lemus Bravo, Ana Elena:
Univ Autonoma Metropolitana, Unidad Iztapalapa, Dept Biol Reprod, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Mexico City, DF, Mexico
Samano, Reyna:
Inst Nacl Perinatol, Dept Nutr & Bioprogramac, Mexico City, DF, Mexico
Tolentino Dolores, Maricruz:
Inst Nacl Perinatol, Dept Nutr & Bioprogramac, Mexico City, DF, Mexico
Rodriguez Ventura, Ana Lilia:
Inst Nacl Perinatol, Dept Nutr & Bioprogramac, Mexico City, DF, Mexico
Juarez Gonzalez, Ana Rosa:
Inst Nacl Perinatol, Dept Nutr & Bioprogramac, Mexico City, DF, Mexico
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