Participation of HHIP gene variants in COPD susceptibility, lung function, and serum and sputum protein levels in women exposed to biomass-burning smoke
Por:
Ortega-Martinez, Alejandro, Perez-Rubio, Gloria, Ramirez-Venegas, Alejandra, Ramirez-Diaz, Maria Elena, Cruz-Vicente, Filiberto, Martínez-Gómez M.D.L., Ramos-Martinez, Espiridion, Abarca-Rojano, Edgar, Falfan-Valencia, Ramces
Publicada:
1 ene 2020
Categoría:
Clinical biochemistry
Resumen:
Background: A variety of organic materials (biomass) are burned for cooking and heating purposes in poorly ventilated houses; smoke from biomass combustion is considered an environmental risk factor for chronic obstructive pulmonary disease COPD. In this study, we attempted to determine the participation of single-nucleotide variants in the HHIP (hedgehog-interacting protein) gene in lung function, HHIP serum levels, and HHIP sputum supernatant levels in Mexican women with and without COPD who were exposed to biomass-burning smoke. Methods: In a case-control study (COPD-BS, n = 186, BBES, n = 557) in Mexican women, three SNPs (rs13147758, rs1828591, and rs13118928) in the HHIP gene were analyzed by qPCR; serum and supernatant sputum protein levels were determined through ELISA. Results: The rs13118928 GG genotype is associated with decreased risk (p = 0.021, OR = 0.51, CI95% = 0.27–0.97) and the recessive genetic model (p = 0.0023); the rs1828591-rs13118928 GG haplotype is also associated with decreased risk (p = 0.04, OR = 0.65, CI95% 0.43–0.98). By the dominant model (rs13118928), the subjects with one or two copies of the minor allele (G) exhibited higher protein levels. Additionally, two correlations with the AG genotype were identified: BBES with FEV1 (p = 0.03, r2 = 0.53) and COPD-BS with FEV1/FVC (p = 0.012, r2 = 0.54). Conclusions: Single-nucleotide variants in the HHIP gene are associated with decreased COPD risk, higher HHIP serum levels, and better lung function in Mexican women exposed to biomass burning. © 2020 by the authors.
Filiaciones:
Ortega-Martinez, Alejandro:
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, 14080, Mexico
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomas, Mexico City, 11340, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, HLA Lab, Mexico City 14080, DF, Mexico
Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad & Invest, Plan San Luis & Diaz Miron S-N, Mexico City 11340, DF, Mexico
Perez-Rubio, Gloria:
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, 14080, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, HLA Lab, Mexico City 14080, DF, Mexico
Ramirez-Venegas, Alejandra:
Tobacco Smoking and COPD Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, 14080, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Tobacco Smoking & COPD Res Dept, Mexico City 14080, DF, Mexico
Ramirez-Diaz, Maria Elena:
Coordinación de Vigilancia Epidemiológica, Jurisdicción 06 Sierra, Tlacolula de Matamoros Oaxaca, Servicios de Salud de Oaxaca, Oaxaca, 70400, Mexico
Jurisdicc 06 Sierra, Coordinac Vigilancia Epidemiol, Serv Salud Oaxaca, Tlacolula De Matamoros 70400, Oaxaca, Mexico
Cruz-Vicente, Filiberto:
Internal Medicine Department., Hospital Civil Aurelio Valdivieso, Servicios de Salud de Oaxaca, Oaxaca, 68050, Mexico
Hosp Civil Aurelio Valdivieso, Serv Salud Oaxaca, Internal Med Dept, Oaxaca 68050, Oaxaca, Mexico
Martínez-Gómez M.D.L.:
Hospital Regional de Alta Especialidad de Oaxaca, Oaxaca, 71256, Mexico
Ramos-Martinez, Espiridion:
Experimental Medicine Research Unit, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, 06720, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Expt Med Res Unit, Mexico City 06720, DF, Mexico
Abarca-Rojano, Edgar:
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomas, Mexico City, 11340, Mexico
Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad & Invest, Plan San Luis & Diaz Miron S-N, Mexico City 11340, DF, Mexico
Falfan-Valencia, Ramces:
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, 14080, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, HLA Lab, Mexico City 14080, DF, Mexico
Hosp Reg Alta Especialidad Oaxaca, Oaxaca 71256, Oaxaca, Mexico
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