PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer's Disease
Por:
Luna-Viramontes, Nabil Itzi, Campa-Cordoba, B. Berenice, Ontiveros-Torres, Miguel Angel, Harrington, Charles R., Villanueva-Fierro, Ignacio, Guadarrama-Ortiz, Parmenides, Garces-Ramirez, Linda, de la Cruz, Fidel, Hernandes-Alejandro, Mario, Martinez-Robles, Sandra, Gonzalez-Ballesteros, Erik, Pacheco-Herrero, Mar, Luna-Munoz, Jose
Publicada:
10 sep 2020
Categoría:
Cellular and molecular neuroscience
Resumen:
Worldwide, around 50 million people have dementia. Alzheimer's disease
(AD) is the most common type of dementia and one of the major causes of
disability and dependency among the elderly worldwide. Clinically, AD is
characterized by impaired memory accompanied by other deficiencies in
the cognitive domain. Neuritic plaques (NPs) and neurofibrillary tangles
(NFTs) are histopathological lesions that define brains with AD. NFTs
consist of abundant intracellular paired helical filaments (PHFs) whose
main constituent is tau protein. Tau undergoes posttranslational changes
including hyperphosphorylation and truncation, both of which favor
conformational changes in the protein. The sequential pathological
processing of tau is illustrated with the following specific markers:
pT231, TG3, AT8, AT100, and Alz50. Two proteolysis sites for tau have
been described-truncation at glutamate 391 and at aspartate 421-and
which can be demonstrated by reactivity with the antibodies 423 and
TauC-3, respectively. In this review, we describe the molecular changes
in tau protein as pre-NFTs progress to extracellular NFTs and during
which the formation of a minimal nucleus of the filament, as the PHF
core, occurs. We also analyzed the PHF core as the initiator of PHFs and
tau phosphorylation as a protective neuronal mechanism against the
assembly of the PHF core.
Filiaciones:
Luna-Viramontes, Nabil Itzi:
Univ Nacl Autonoma Mexico, Fac Estudios Super, Dept Ciencias Biol, Natl Dementia BioBank, Mexico City, DF, Mexico
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Fisiol, Mexico City, DF, Mexico
Campa-Cordoba, B. Berenice:
Univ Nacl Autonoma Mexico, Fac Estudios Super, Dept Ciencias Biol, Natl Dementia BioBank, Mexico City, DF, Mexico
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Fisiol, Mexico City, DF, Mexico
Ontiveros-Torres, Miguel Angel:
Tecnol Monterrey, Sch Engn & Sci, Toluca, Mexico
Harrington, Charles R.:
Univ Aberdeen, Sch Med Med Sci & Nutr, Aberdeen, Scotland
Villanueva-Fierro, Ignacio:
Becario COFAA, Inst Politecn Nacl, CIIDIR, Durango, Mexico
Guadarrama-Ortiz, Parmenides:
CENNM, Ctr Especializado Neurocirugia & Neurociencias Me, Dept Neurocirugia, Mexico City, DF, Mexico
Garces-Ramirez, Linda:
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Fisiol, Mexico City, DF, Mexico
de la Cruz, Fidel:
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Fisiol, Mexico City, DF, Mexico
Hernandes-Alejandro, Mario:
Inst Politecn Nacl UPIBI IPN, Unidad Profes Interdisciplinaria Biotecnol, Dept Bioingn, Mexico City, DF, Mexico
Martinez-Robles, Sandra:
Univ Nacl Autonoma Mexico, Fac Estudios Super, Dept Ciencias Biol, Natl Dementia BioBank, Mexico City, DF, Mexico
Gonzalez-Ballesteros, Erik:
Univ Nacl Autonoma Mexico, Fac Estudios Super, Dept Ciencias Biol, Natl Dementia BioBank, Mexico City, DF, Mexico
Pacheco-Herrero, Mar:
Pontificia Univ Catolica Madre & Maestra, Fac Hlth Sci, Neurosci Res Lab, Santiago De Caballeros, Dominican Rep
Luna-Munoz, Jose:
Univ Nacl Autonoma Mexico, Fac Estudios Super, Dept Ciencias Biol, Natl Dementia BioBank, Mexico City, DF, Mexico
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