Recent Advances in Elastin-Based Biomaterials
Por:
Luisa Del Prado-Audelo, Maria, Mendoza-Munoz, Nestor, Escutia-Guadarrama, Lidia, Giraldo-Gomez, David, Gonzalez-Torres, Maykel, FLORAN, BENJAMIN, Cortes, Hernan, Leyva-Gomez, Gerardo
Publicada:
13 ago 2020
Resumen:
Elastin is one of the main components of the extracellular matrix; it
provides resistance and elasticity to a variety of tissues and organs of
the human body, besides participating in cellular signaling. In
addition, elastin-derived peptides are synthetic biopolymers with a
similar conformation and structure to elastin, but these possess the
advantage of solubility in aqueous mediums. Due to their biological
activities and physicochemical properties, elastin and related peptides
may be applied as biomaterials to develop diverse biomedical devices,
including scaffolds, hydrogels, and drug delivery systems for tissue
engineering. Likewise, the combination of elastin with natural or
synthetic polymers has demonstrated to improve the mechanical properties
of biomedical products and drug delivery systems. Here we
comprehensively describe the physicochemical properties and
physiological functions of elastin. Moreover, we offer an overview of
the use of elastin and its derivative polymers as biomaterials to
develop scaffolds and hydrogels for tissue engineering. Finally, we
discuss some perspectives on the employment of these biopolymers to
fabricate new biomedical products.
Filiaciones:
Luisa Del Prado-Audelo, Maria:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad De Mexico 04510, Mexico
Tecnol Monterrey, Dept Bioingn, Escuela Ingn & Ciencias, Campus Ciudad Mexico, Ciudad De Mexico 14380, Mexico
Mendoza-Munoz, Nestor:
Univ Colima, Fac Ciencias Quim, Colima 28400, Mexico
Escutia-Guadarrama, Lidia:
Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Fis, Ciudad De Mexico 04510, Mexico
Giraldo-Gomez, David:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Microscopia, Ciudad De Mexico 04510, Mexico
Gonzalez-Torres, Maykel:
Inst Nacl Rehabil Luis Guilleinio Ibarra Ibarra, Lab Biotecnol, CONACyT, Ciudad De Mexico 14389, Mexico
FLORAN, BENJAMIN:
Inst Politecn Nacl, Dept Fisiol Biofis & Neurociencias, Ctr Invest & Estudios Avanzados, Ciudad De Mexico 07360, Mexico
Cortes, Hernan:
Inst Nacl Rehabil Luis Guille Ibarra Ibarra, Dept Genom, Lab Med Genom, Ciudad De Mexico 14389, Mexico
Leyva-Gomez, Gerardo:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad De Mexico 04510, Mexico
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