An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection
Por:
Romero-Navarrete M., Ruíz L.F., Castillo A., Arenas R., Vega-Memije M.E., Xicohtencatl-Cortes J., Espinoza-Rivera M., Hernández-Castro R.
Publicada:
1 ene 2018
Categoría:
Infectious diseases
Resumen:
Chromoblastomycosis is defined as a chronic cutaneous and subcutaneous fungal infection caused by melanized or brown-pigmented fungi. A 63-year-old man farmer showed on external and internal part of the right arm, a well-delimited verrucous and hyperkeratotic plaque, with atrophic and cicatricial areas. Direct examination of skin scrapings samples showed the presence of muriform cells, a classic feature of chromoblastomycosis. Fungal isolation was performed in Sabouraud dextrose agar, and dark olivaceous colonies were isolated. Skin biopsy samples were obtained for histopathological and molecular diagnosis. DNA extracted from both, paraffin-embedded skin biopsy samples and fungal colonies, was used for molecular identification by 18S-ITS1-5.8S-ITS2-28S rRNA amplification and sequencing. Fonsecaea pedrosoi was identified from paraffin-embedded skin samples and fungal colonies. A combined therapy with terbinafine and itraconazole, plus cryotherapy was applied with an important improvement. Herein, we report an impressive case of chromoblastomycosis due to Fonsecaea pedrosoi with a successful outcome. © 2018 Elsevier Masson SAS
Filiaciones:
Romero-Navarrete M.:
Hospital General-de-Acapulco, Secretaria de Salud, Guerrero, 39670, Mexico
Ruíz L.F.:
Servicio de Dermatopatología, Hospital General “Dr. Manuel Gea González”, Tlalpan, 14080, Mexico
Castillo A.:
Hospital General-de-Acapulco, Secretaria de Salud, Guerrero, 39670, Mexico
Arenas R.:
Servicio de Micología, Hospital General Dr. Manuel Gea González, Tlalpan, 14080, Mexico
Vega-Memije M.E.:
Servicio de Dermatopatología, Hospital General “Dr. Manuel Gea González”, Tlalpan, 14080, Mexico
Xicohtencatl-Cortes J.:
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Dr. Federico Gómez, Cuauhtémoc, 06720, Mexico
Espinoza-Rivera M.:
Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, Tlalpan, 14080, Mexico
Hernández-Castro R.:
Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, Tlalpan, 14080, Mexico
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