GSTT1 and GSTM1 null variants in mestizo and amerindian populations from Northwestern Mexico and a literature review
Por:
Palma-Cano L.E., Córdova E.J., Orozco L., Martínez-Hernández A., Cid M., Leal-Berumen I., Licón-Trillo A., Lechuga-Valles R., González-Ponce M., González-Rodríguez E., Moreno-Brito V.
Publicada:
1 ene 2017
Resumen:
The GSTT1 and GSTM1 genes are key molecules in cellular detoxification. Null variants in these genes are associated with increase susceptibility to developing different types of cancers. The aim of this study was to determine the prevalence of GSTT1 and GSTM1 null genotypes in Mestizo and Amerindian individuals from the Northwestern region of Mexico, and to compare them with those reported worldwide. GSTT1 and GSTM1 null variants were genotyped by multiplex PCR in 211 Mestizos and 211 Amerindian individuals. Studies reporting on frequency of GSTT1 and GSTM1 null variants worldwide were identified by a PubMed search and their geographic distribution were analyzed. We found no significant differences in the frequency of the null genotype for GSTT1 and GSM1 genes between Mestizo and Amerindian individuals. Worldwide frequencies of the GSTT1 and GSTM1 null genotypes ranges from 0.10 to 0.51, and from 0.11 to 0.67, respectively. Interestingly, in most countries the frequency of the GSTT1 null genotype is common or frequent (76%), whereas the frequency of the GSMT1 null genotype is very frequent or extremely frequent (86%). Thus, ethnic-dependent differences in the prevalence of GSTT1 and GSTM1 null variants may influence the effect of environmental carcinogens in cancer risk. © 2017, Sociedade Brasileira de Genética. Printed in Brazil.
Filiaciones:
Palma-Cano L.E.:
Department of Biochemistry, Faculty of Medicine and Biomedical Science, Autonomus University of Chihuahua, Chihuahua, Chihuahua, Mexico
Córdova E.J.:
Department of Clinical Research, National Institute of Genomic Medicine, Mexico City, Mexico
Orozco L.:
Department of Clinical Research, National Institute of Genomic Medicine, Mexico City, Mexico
Martínez-Hernández A.:
Department of Clinical Research, National Institute of Genomic Medicine, Mexico City, Mexico
Cid M.:
Department of Clinical Research, National Institute of Genomic Medicine, Mexico City, Mexico
Leal-Berumen I.:
Department of Biochemistry, Faculty of Medicine and Biomedical Science, Autonomus University of Chihuahua, Chihuahua, Chihuahua, Mexico
Licón-Trillo A.:
Department of Biochemistry, Faculty of Medicine and Biomedical Science, Autonomus University of Chihuahua, Chihuahua, Chihuahua, Mexico
Lechuga-Valles R.:
Department of Molecular Biology, Faculty of Zootechnics and Ecology, Autonomus University of Chihuahua, Chihuahua, Chihuahua, Mexico
González-Ponce M.:
Department of Biochemistry, Faculty of Medicine and Biomedical Science, Autonomus University of Chihuahua, Chihuahua, Chihuahua, Mexico
González-Rodríguez E.:
Department of Molecular Biology, Faculty of Zootechnics and Ecology, Autonomus University of Chihuahua, Chihuahua, Chihuahua, Mexico
Moreno-Brito V.:
Department of Biochemistry, Faculty of Medicine and Biomedical Science, Autonomus University of Chihuahua, Chihuahua, Chihuahua, Mexico
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