The presence of herpes simplex-1 and varicella zoster viruses is not related with clinical outcome of Bell's Palsy
Por:
Ordoñez G., Vales O., Pineda B., Rodríguez K., Pane C., Sotelo J.
Publicada:
1 ene 2020
Categoría:
Virology
Resumen:
Bell's Palsy is the most frequent acute neuropathy of cranial nerves; it has been associated in various reports to herpes viruses. In a prospective study we searched the presence of DNA from five herpes viruses (HSV-1 and 2, VZV, EBV and HHV-6) in 79 patients at the acute phase of Bell's Palsy. Results were related with various parameters; age, gender and clinical outcome. We found the significant presence (p?0.001) of HSV-1 and VZV in 39% and 42% of patients. However, a large percentage of cases were negative. When comparisons were made between subgroups according to gender and age no differences were found with viral findings nor with clinical outcome of palsy, which was of clinical remission in most cases (78%). Our results suggest that herpes viruses might participate in the complex mechanisms of autoimmunity of Bell's Palsy but not as determinant etiological element. © 2020 Elsevier Inc.
Filiaciones:
Ordoñez G.:
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City, 14269, Mexico
Vales O.:
Department of Neuro-otology, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City, 14269, Mexico
Pineda B.:
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City, 14269, Mexico
Rodríguez K.:
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City, 14269, Mexico
Pane C.:
Department of Neuro-otology, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City, 14269, Mexico
Sotelo J.:
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City, 14269, Mexico
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