Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients with Acute Leukemia
Por:
Reyna-Figueroa J., Barrón-Calvillo E., García-Parra C., Galindo-Delgado P., Contreras-Ochoa C., Lagunas-Martínez A., Campos-Romero F.H., Silva-Estrada J.A., Limón-Rojas A.E.
Publicada:
1 ene 2019
Resumen:
Introduction:In children with acute leukemia, gut microbiota is modified secondary to chemotherapy administration, leading to gastrointestinal side effects. Probiotics are microorganisms that can restore gut microbiota and may help alleviate gastrointestinal symptoms. The aim of this pilot study was to assess the effects of probiotic supplementation on chemotherapy-induced gastrointestinal side effects in children with acute leukemia (AL).Methods:In this randomized pilot study, patients under 17 years of age diagnosed with AL who were on remission induction or remission reinduction chemotherapy were randomly assigned to receive probiotic supplementation (a concentration of 5×109 CFU per sachet was administered at a standard dose twice daily, by mouth) or no probiotic supplementation. The primary endpoint was the prevalence of gastrointestinal side effects. Vomiting, nausea, flatulence, dyspepsia, diarrhea, constipation, abdominal pain, and abdominal distention were assessed in both groups.Results:Gastrointestinal side effects were less prevalent in the probiotic group, and 3 of the 8 gastrointestinal side effects (nausea, vomiting, and abdominal distension) significantly decreased in the probiotic group (P<0.05). We found for diarrhea a relative risk of 0.5 (95% confidence interval [CI], 0.2-1.2; P=0.04); for nausea an RR of 0.5 (95% CI, 0.4-0.8; P=0.04) and for vomiting an RR of 0.4 (95% CI, 0.2-0.9; P=0.04).Conclusions:Daily supplementation with Lactobacillus rhamnosus reduced chemotherapy-induced gastrointestinal side effects in children with AL. © 2019 Lippincott Williams and Wilkins. All rights reserved.
Filiaciones:
Reyna-Figueroa J.:
Pediatrician-Infectologist, of Health Sciences Public, Central South Hospital of High Specialty, Anillo Periférico (Blvd. Adolfo Ruiz Cortines) 4091, Ciudad de Mexico Distrito Federal, Mexico
Barrón-Calvillo E.:
Pediatrician, Central South Hospital of High Specialty
García-Parra C.:
Pediatrician, Central South Hospital of High Specialty
Galindo-Delgado P.:
Pediatrician, Central South Hospital of High Specialty
Hematologist- Pediatrician, Central South Hospital of High Specialty, Petroleos Mexicanos, Mexico
Central South Hospital of High Specialty, Petroleos Mexicanos, Mexico
Contreras-Ochoa C.:
National Institute of Public Health
Lagunas-Martínez A.:
National Institute of Public Health
Campos-Romero F.H.:
Central South Hospital of High Specialty, Petroleos Mexicanos, Mexico
Silva-Estrada J.A.:
Pediatrician, Central South Hospital of High Specialty
Limón-Rojas A.E.:
Pediatrician, Central South Hospital of High Specialty
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