Antiallodynic Effect of Piperine in Neuropathic Rats
Por:
Sanchez-Trujillo, Luis Arturo, Mendoza-Monroy, Jorge Luis, Rocha-Gonzalez, Hector Isaac, Quiñonez-Bastidas G.N., Balderas-Lopez, Jose Luis, Navarrete, Andres
Publicada:
1 ago 2020
Ahead of Print:
1 ene 2020
Categoría:
Pharmacology, toxicology and pharmaceutics (miscellaneous)
Resumen:
Neuropathic pain is a disabling syndrome difficult to manage. Currently, pharmacological treatment of neuropathic patients provides an unsatisfactory relief of pain. Recent reports suggested that piperine has anti-inflammatory and antinociceptive effects. Therefore, the aim of this study was to investigate the antiallodynic effect of piperine, as well as the possible antinociceptive mechanism involved in its antiallodynic effect. Piper nigrum L., Piperaceae, was used to extract the piperine. Spinal nerve ligation L5/L6 model was used to induce allodynia in rats. Intraperitoneal administration of increasing doses of piperine (3.1–100 mg/kg) reduced allodynia in rats. The administration of capsazepine (selective TRPV1 antagonist, 5 and 30 µg/i.t.) and bicuculline (GABAA antagonist, 3 and 30 µg/i.t.), but not SKF-96365 (TRPC antagonist, 3 and 30 µg/i.t.), prevented the piperine-induced (56 mg/kg, i.p.) antiallodynic effect in a dose-dependent manner. HC-030031 (selective TRPA1 antagonist, 3 and 30 µg/i.t.) avoided only partially piperine-induced (56 mg/kg, i.p.) antiallodynic effect. Data suggest that piperine induces antiallodynic effect in neuropathic rats, and its antiallodynic effect involves the activation of TRPV1 and GABAA receptors. Piperine could be useful to treat neuropathic pain in human beings. [Figure not available: see fulltext.]. © 2020, Sociedade Brasileira de Farmacognosia.
Filiaciones:
Sanchez-Trujillo, Luis Arturo:
Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad Univ, Mexico City, DF, Mexico
Mendoza-Monroy, Jorge Luis:
Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad Univ, Mexico City, DF, Mexico
Rocha-Gonzalez, Hector Isaac:
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Mexico City, 11340, Mexico
Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Escuela Super Med, Plan San Luis & Diaz Miron S-N, Mexico City 11340, DF, Mexico
Quiñonez-Bastidas G.N.:
Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, Mexico
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Mexico City, 11340, Mexico
Balderas-Lopez, Jose Luis:
Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad Univ, Mexico City, DF, Mexico
Navarrete, Andres:
Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad Univ, Mexico City, DF, Mexico
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