Rituximab as an effective therapeutic option in refractory Neuro-Behçet syndrome
Por:
Garcia-Estrada C., Casallas-Vanegas A., Zabala-Angeles I., Gomez-Figueroa E., Rivas-Alonso V., Flores-Rivera J.
Publicada:
1 ene 2020
Resumen:
Introduction: Behçet's disease (BD) is an inflammatory disease of unknown etiology with periods of relapses and remissions. Neuro-Behçet syndrome (NBS) is one of the main causes of long-term morbidity and mortality, making its prompt recognition and early treatment fundamental to achieving a better outcome. Currently there are no treatment guidelines either for BS or NB, making the management of these patients particularly difficult. Case presentation: We present the case report of a patient with pseudo-tumoral lesion and myelitis refractory to steroids and cyclophosphamide who successfully showed remission after treatment with an anti-CD20 therapy. Conclusion: This is the first report of concomitant pseudo-tumoral lesion and myelitis secondary to BS. We found rituximab treatment to be a safe and effective therapeutic option for NB supported by the radiological and clinical improvement achieved in our patient. © 2020 Elsevier B.V.
Filiaciones:
Garcia-Estrada C.:
Multiple Sclerosis and Demyelinating Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Casallas-Vanegas A.:
Multiple Sclerosis and Demyelinating Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Zabala-Angeles I.:
Multiple Sclerosis and Demyelinating Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Gomez-Figueroa E.:
Multiple Sclerosis and Demyelinating Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Rivas-Alonso V.:
Multiple Sclerosis and Demyelinating Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Flores-Rivera J.:
Multiple Sclerosis and Demyelinating Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Head of Neurology Department National Institute of Neurology and Neurosurgery, Mexico City, Mexico
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