Genetic association analysis of 5-HTR2A gene variants in eating disorders in a Mexican population
Por:
Genis-Mendoza A.D., Ruiz-Ramos D., López-Narvaez M.L., Tovilla-Zárate C.A., Rosa García A., Cortes Meda G., Martinez-Magaña J.J., González-Castro T.B., Juárez-Rojop I.E., Nicolini H.
Publicada:
1 ene 2019
Categoría:
Behavioral neuroscience
Resumen:
Introduction: The 5-HTR2A gene has been implicated as candidate gene for eating disorders. The aim of the present study was to analyze the association of rs6311 and rs6313 polymorphisms of 5-HTR2A gene with eating disorders in Mexican population, and to evaluate if the polymorphisms of 5-HTR2A gene were associated with comorbidities in eating behavior. Methods: We conducted a case–control analysis with 460 subjects. We included 168 patients with eating disorders and 292 controls; two polymorphisms of 5-HTR2A gene were genotyped. We assessed the association by allele, genotype, and inheritance models. Psychiatric comorbidities were analyzed by genotype in patients with eating disorders. Results: We found an association between rs6311 and eating disorders in a Mexican population by allele (OR = 8.09; 95% CI = 5.99–11.03; p = 2.2e-16) and genotype (OR = 76.14; 95% CI = 35.61–177.18; p = 2.2e-16). Individuals who carried GG genotype showed increased risk for suicide attempted (OR = 2.14; CI = 1.10–4.26; p = 0.035) as comorbidity associated with eating disorders. No positive associations were observed for rs6313 polymorphism. Conclusion: Our results showed an association of rs6311 (A1438G) polymorphism of 5-HTR2A gene with eating disorders, and these polymorphic variants could increase the risk of psychiatric comorbidities. However, more studies are required to replicate the results and to reach to a conclusive association between eating disorders and rs6311. © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
Filiaciones:
Genis-Mendoza A.D.:
Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, Mexico
Ruiz-Ramos D.:
División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico
López-Narvaez M.L.:
Hospital General de Yajalón “Manuel Velazco Suarez”, Secretaría de Salud, Yajalón, Chiapas, Mexico
Tovilla-Zárate C.A.:
División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, Mexico
Rosa García A.:
Hospital Psiquiátrico Infantil Juan N Navarro, Secretaría de Salud, Ciudad de México, Mexico
Cortes Meda G.:
Hospital Psiquiátrico Infantil Juan N Navarro, Secretaría de Salud, Ciudad de México, Mexico
Martinez-Magaña J.J.:
Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, Mexico
González-Castro T.B.:
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, Mexico
Juárez-Rojop I.E.:
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, Mexico
Nicolini H.:
Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, Mexico
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