Effects of metformin on recognition memory and hippocampal neuroplasticity in rats with metabolic syndrome
Por:
Munoz-Arenas, Guadalupe, Pulido, Guadalupe, Trevino, Samuel, Vazquez-Roque, Ruben, Flores, Gonzalo, Moran, Carolina, Handal-Silva, Anabella, Guevara, Jorge, Venegas, Berenice, Diaz, Alfonso
Publicada:
1 sep 2020
Categoría:
Cellular and molecular neuroscience
Resumen:
Metabolic syndrome (MS) is a health problem that is characterized by
body fat accumulation, hypertension, dyslipidemia, and hyperglycemia;
recently, it has been demonstrated that MS also damages memory
processes. The first-line drug in the treatment of MS and type 2
diabetes mellitus is metformin, which is an antihyperglycemic agent.
This drug has been shown to produce neuroprotection and to improve
memory processes. However, the mechanism involved in this
neuroprotection is unknown. A 90-day administration of metformin
improved the cognitive processes of rats with MS as evaluated by the
novel object recognition test, and this finding could be explained by an
increase in the neuronal spine density and spine length. We also found
that metformin increased the immunoreactivity of synaptophysin,
sirtuin-1, AMP-activated protein kinase, and brain-derived neuronal
factor, which are important plasticity markers. We conclude that
metformin is an important therapeutic agent that increases neural
plasticity and protects cognitive processes. The use of this drug is
important in the minimization of the damage caused by MS.
Filiaciones:
Munoz-Arenas, Guadalupe:
Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, 14 Sur 6301, Puebla 72570, Mexico
Pulido, Guadalupe:
Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, 14 Sur 6301, Puebla 72570, Mexico
Trevino, Samuel:
Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, 14 Sur 6301, Puebla 72570, Mexico
Vazquez-Roque, Ruben:
Benemerita Univ Autonoma Puebla, Inst Fisiol, Lab Neuropsiquiatria, Puebla, Mexico
Flores, Gonzalo:
Benemerita Univ Autonoma Puebla, Inst Fisiol, Lab Neuropsiquiatria, Puebla, Mexico
Moran, Carolina:
Benemerita Univ Autonoma Puebla, Inst Ciencias, Lab Histol, Puebla, Mexico
Handal-Silva, Anabella:
Benemerita Univ Autonoma Puebla, Inst Ciencias, Dept Biol & Toxicol Reprod, Puebla, Mexico
Guevara, Jorge:
Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad De Mexico, Mexico
Venegas, Berenice:
Benemerita Univ Autonoma Puebla, Fac Ciencias Biol, 14 Sur 6301, Puebla 72570, Mexico
Diaz, Alfonso:
Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, 14 Sur 6301, Puebla 72570, Mexico
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