Rhamnolipids stabilize quorum sensing mediated cooperation in Pseudomonas aeruginosa
Por:
Garcia-Contreras, Rodolfo, Loarca, Daniel, Perez-Gonzalez, Caleb, Jimenez-Cortes, J. Guillermo, Gonzalez-Valdez, Abigail, Soberon-Chavez, Gloria
Publicada:
1 may 2020
Resumen:
Pseudomonas aeruginosa is one of the main models to study social
behaviors in bacteria since it synthesizes several exoproducts,
including exoproteases and siderophores and release them to the
environment. Exoproteases and siderophores are public goods that can be
utilized by the individuals that produce them but also by non-producers,
that are considered social cheaters. Molecularly exoprotease cheaters
are mutants in regulatory genes such as lasR, and are commonly isolated
from chronic infections and selected in the laboratory upon serial
cultivation in media with protein as a sole carbon source. Despite that
the production of exoproteases is exploitable, cooperators have also
ways to restrict the growth and selection of social cheaters, for
instance by producing toxic metabolites like pyocyanin. In this work,
using bacterial competitions, serial cultivation and growth assays, we
demonstrated that rhamnolipids which production is regulated by quorum
sensing, selectively affect the growth of lasR mutants and are able to
restrict social cheating, hence contributing to the maintenance of
cooperation in Pseudomonas aeruginosa populations.
Filiaciones:
Garcia-Contreras, Rodolfo:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Copilco Universidad, Coyoacán, Mexico City 04360, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Circuto Escolar 411A, Mexico City 04360, DF, Mexico
Loarca, Daniel:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Copilco Universidad, Coyoacán, Mexico City 04360, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Circuto Escolar 411A, Mexico City 04360, DF, Mexico
Perez-Gonzalez, Caleb:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Copilco Universidad, Coyoacán, Mexico City 04360, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Circuto Escolar 411A, Mexico City 04360, DF, Mexico
Jimenez-Cortes, J. Guillermo:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Copilco Universidad, Coyoacán, Mexico City 04360, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Circuto Escolar 411A, Mexico City 04360, DF, Mexico
Gonzalez-Valdez, Abigail:
Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, CDMX, Ciudad Universitaria ,Apdo. Postal 70228C. P. 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Mol & Biotecnol, Ciudad Univ,Apdo Postal 70228, Mexico City 04510, DF, Mexico
Soberon-Chavez, Gloria:
Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, CDMX, Ciudad Universitaria ,Apdo. Postal 70228C. P. 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Mol & Biotecnol, Ciudad Univ,Apdo Postal 70228, Mexico City 04510, DF, Mexico
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