Phytochemical constituents, antioxidant, cytotoxic, and antimicrobial activities of the ethanolic extract of mexican brown propolis
Por:
Rivero-Cruz J.F., Granados-Pineda, Jessica, Pedraza-Chaverri, Jose, Pérez-Rojas J.M., Kumar-Passari, Ajit, Diaz-Ruiz, Gloria, Rivero-Cruz B.E.
Publicada:
1 ene 2020
Resumen:
Propolis is a complex mixture of natural sticky and resinous components produced by honeybees from living plant exudates. Globally, research has been dedicated to studying the biological properties and chemical composition of propolis from various geographical and climatic regions. However, the chemical data and biological properties of Mexican brown propolis are scant. The antioxidant activity of the ethanolic extract of propolis (EEP) sample collected in México and the isolated compounds is described. Cytotoxic activity was evaluated in a central nervous system and cervical cancer cell lines. Cytotoxicity of EEP was evaluated in a C6 cell line and cervical cancer (HeLa, SiHa, and CasKi) measured by the 3-(3,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium (MTT) assay. The antibacterial activity was tested using the minimum inhibitory concentration (MIC) assay. Twelve known compounds were isolated and identified by nuclear magnetic resonance spectroscopy (NMR). Additionally, forty volatile compounds were identified by means of headspace-solid phase microextraction with gas chromatography and mass spectrometry time of flight analysis (HS-SPME/GC-MS-TOF). The main volatile compounds detected include nonanal (18.82%), a-pinene (12.45%), neryl alcohol (10.13%), and a-pinene (8.04%). EEP showed an anti-proliferative effect on glioma cells better than temozolomide, also decreased proliferation and viability in cervical cancer cells, but its effectiveness was lower compared to cisplatin. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Rivero-Cruz J.F.:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Granados-Pineda, Jessica:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Ciudad Univ, Ciudad De Mexico 04510, Mexico
Pedraza-Chaverri, Jose:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Ciudad Univ, Ciudad De Mexico 04510, Mexico
Pérez-Rojas J.M.:
División de Investigación Básica, Instituto Nacional de Cancerología, Av. San Fernando 22, Apartado Postal 22026, Tlalpan, 14000, Mexico
Kumar-Passari, Ajit:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Ciudad Univ, Ciudad De Mexico 04510, Mexico
Diaz-Ruiz, Gloria:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Ciudad Univ, Ciudad De Mexico 04510, Mexico
Rivero-Cruz B.E.:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Inst Nacl Cancerol, Div Invest Basica, Av San Fernando 22,Apartado Postal 22026, Tlalpan 14000, Mexico
|